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Using Optical Tweezersto Probe Dna Polymerase Kappa’S Binding Mechanism To Dna, Joshua Watts
Using Optical Tweezersto Probe Dna Polymerase Kappa’S Binding Mechanism To Dna, Joshua Watts
Honors Program Theses and Projects
The integrity of our DNA is constantly under threat from many internal and external factors. If the cell cannot properly protect the integrity of DNA, errors (lesions) in DNA may form which can lead to cancer. Most of these lesions serve as a roadblock to the protein, DNA polymerase (Pol), that replicates the DNA during cell division. The mechanism that is employed to read through these errors is called translesion DNA synthesis (TLS). During this process, a special class of DNA polymerases known as TLS DNA Pols that can tolerate and bypass the lesions in DNA are employed by the …