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Full-Text Articles in Physics
Exploring The Interaction Of Minor-Groove-Binder Netropsin With Dna Using Optical Tweezers, Irbazhusain Shaikh
Exploring The Interaction Of Minor-Groove-Binder Netropsin With Dna Using Optical Tweezers, Irbazhusain Shaikh
Honors Program Theses and Projects
Netropsin is an antibiotic that binds in the minor grooves of DNA, which also exhibits anticancer properties. There have been many previous studies that explored the binding of this drug to DNA using traditional methods where an ensemble averaging is used. In this study we explore the interaction of Netropsin with DNA at a single molecule level using dual beam optical tweezers. We trapped and stretched a single DNA molecule using optical tweezers to measure the force experienced by the DNA as a function of extension in the absence and presence of various concentrations of Netropsin. Our results show the …
Using Optical Tweezersto Probe Dna Polymerase Kappa’S Binding Mechanism To Dna, Joshua Watts
Using Optical Tweezersto Probe Dna Polymerase Kappa’S Binding Mechanism To Dna, Joshua Watts
Honors Program Theses and Projects
The integrity of our DNA is constantly under threat from many internal and external factors. If the cell cannot properly protect the integrity of DNA, errors (lesions) in DNA may form which can lead to cancer. Most of these lesions serve as a roadblock to the protein, DNA polymerase (Pol), that replicates the DNA during cell division. The mechanism that is employed to read through these errors is called translesion DNA synthesis (TLS). During this process, a special class of DNA polymerases known as TLS DNA Pols that can tolerate and bypass the lesions in DNA are employed by the …
Realization Of Bsu First Magneto-Optical Trap For The Spatial Confinement Of Rb Atoms Using Next Generation Fiber Optic Capabilities With Minimot, Brahmin Thurber-Carbone
Realization Of Bsu First Magneto-Optical Trap For The Spatial Confinement Of Rb Atoms Using Next Generation Fiber Optic Capabilities With Minimot, Brahmin Thurber-Carbone
Honors Program Theses and Projects
This paper will be a combination of my theoretical and experimental work toward Bridgewater State Universities first Magneto-Optical Trap (MOT) for laser cooling and trapping of neutral atoms in order to study fundamental quantum mechanical behavior of Rubidium (Rb) atoms. The goal of the theoretical aspect is to complete details of well-established works on how the complicated quantum, atomic, and electromagnetic (laser) interactions required to understand the design and operation of the MOT reduce to the physics and mathematics of a damped oscillator. This is made explicitly clear using familiar damped oscillator systems, such as a spring/mass/damping or pendulum/mass/damping (ie …