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Full-Text Articles in Physics
Analogs Of Ldl Receptor Ligand Motifs In Dengue Envelope And Capsid Proteins As Potential Codes For Cell Entry, Juan Guevara Jr., Jamie Romo Jr., Troy Mcwhorter, Natalia Valentinova Guevara
Analogs Of Ldl Receptor Ligand Motifs In Dengue Envelope And Capsid Proteins As Potential Codes For Cell Entry, Juan Guevara Jr., Jamie Romo Jr., Troy Mcwhorter, Natalia Valentinova Guevara
Physics and Astronomy Faculty Publications and Presentations
It is established that cell entry of low density lipoprotein particles (LLPs) containing Apo B100 and Apo E is mediated by receptors and GAGs. Receptor ligand motifs, XBBBXXBX, XBBXBX, and ΨBΨXB, and mono- and bipartite NLS sequences are abundant in Apo E and Apo B100 as well as in envelope and capsid proteins of Dengue viruses 1-4 (DENV1-4). Synthetic, fluorescence-labeled peptides of sequences in DENV2 envelope protein, and DENV3 capsid that include these motifs were used to conduct a qualitative assessment of cell binding and entry capacity using …