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Nanoscale Assembly Of Dectin-1 And Its Glucan Ligand In Immunocyte Membranes And Pathogen Cell Walls, Akram Etemadi Amin
Nanoscale Assembly Of Dectin-1 And Its Glucan Ligand In Immunocyte Membranes And Pathogen Cell Walls, Akram Etemadi Amin
Physics & Astronomy ETDs
Candida spp. pathogens continue to be a significant health care burden with high mortality and exceeding enormous healthcare costs. Candida infection range varies from dermatological infection to more severe bloodstream infection in debilitated patients. Due to this, research dedicated to understanding biophysical interactions between Candida species and the host’s immune cells is essential. The C-type lectin’s (CtLs) are known to bind to Candida cell walls and play a crucial role in downstream immune signaling. It is known that β-glucans, the highly immunogenic polysaccharide in Candida’s cell wall, are mostly masked underneath a layer of mannosylated proteins. The amount of …
Nanoscale Surface Patterning And Applications: Using Top-Down Patterning Methods To Aid Bottom-Up Fabrication, Anthony Craig Pearson
Nanoscale Surface Patterning And Applications: Using Top-Down Patterning Methods To Aid Bottom-Up Fabrication, Anthony Craig Pearson
Theses and Dissertations
Bottom-up self-assembly can be used to create structures with sub-20 nm feature sizes or materials with advanced electrical properties. Here I demonstrate processes to enable such self-assembling systems including block copolymers and DNA origami, to be integrated into nanoelectronic devices. Additionally, I present a method which utilizes the high stability and electrical conductivity of graphene, which is a material formed using a bottom-up growth process, to create archival data storage devices. Specifically, I show a technique using block copolymer micelle lithography to fabricate arrays of 5 nm gold nanoparticles, which are chemically modified with a single-stranded DNA molecule and used …