Open Access. Powered by Scholars. Published by Universities.®
Other Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
University of Massachusetts Amherst
Mathematics and Statistics Department Faculty Publication Series
Articles 1 - 1 of 1
Full-Text Articles in Other Physical Sciences and Mathematics
Immune Classification Of Osteosarcoma, Trang Le, Sumeyye Su, Leili Shahriyari
Immune Classification Of Osteosarcoma, Trang Le, Sumeyye Su, Leili Shahriyari
Mathematics and Statistics Department Faculty Publication Series
Tumor immune microenvironment has been shown to be important in predicting the tumor progression and the outcome of treatments. This work aims to identify different immune patterns in osteosarcoma and their clinical characteristics. We use the latest and best performing deconvolution method, CIBERSORTx, to obtain the relative abundance of 22 immune cells. Then we cluster patients based on their estimated immune abundance and study the characteristics of these clusters, along with the relationship between immune infiltration and outcome of patients. We find that abundance of CD8 T cells, NK cells and M1 Macrophages have a positive association with prognosis, while …