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Full-Text Articles in Mathematics
Radiotherapy Optimal Design: An Academic Radiotherapy Treatment Design System, R Acosta, W Brick, A Hanna, Allen Holder, D Lara, G Mcquillen, D Nevin, P Uhlig, B Salter
Radiotherapy Optimal Design: An Academic Radiotherapy Treatment Design System, R Acosta, W Brick, A Hanna, Allen Holder, D Lara, G Mcquillen, D Nevin, P Uhlig, B Salter
Mathematical Sciences Technical Reports (MSTR)
Optimally designing radiotherapy and radiosurgery treatments to increase the likelihood of a successful recovery from cancer is an important application of operations research. Researchers have been hindered by the lack of academic software that supports head-to-head comparisons of different techniques, and this article addresses the inherent difficulties of designing and implementing an academic treatment planning system. In particular, this article details the algorithms and the software design of Radiotherapy optimAl Design (RAD).
Beam Selection In Radiotherapy Design, M Ehrgott, Allen G. Holder, Josh Reese
Beam Selection In Radiotherapy Design, M Ehrgott, Allen G. Holder, Josh Reese
Mathematics Faculty Research
The optimal design of a radiotherapy treatment depends on the collection of directions from which radiation is focused on the patient. These directions are manually selected by a physician and are typically based on the physician's previous experiences. Once the angles are chosen, there are numerous optimization models that decide a fluency pattern (exposure times) that best treats a patient. So, while optimization techniques are often used to decide the length of time a patient is exposed to a high-energy particle beam, the directions themselves are not optimized. The problem with optimally selecting directions is that the underlying mixed integer …
The Influence Of Dose Grid Resolution On Beam Selection Strategies In Radiotherapy Treatment Design, Ryan Acosta, Matthias Ehrgott, Allen G. Holder, Daniel Nevin, Josh Reese, Bill Salter
The Influence Of Dose Grid Resolution On Beam Selection Strategies In Radiotherapy Treatment Design, Ryan Acosta, Matthias Ehrgott, Allen G. Holder, Daniel Nevin, Josh Reese, Bill Salter
Mathematics Faculty Research
The design of a radiotherapy treatment includes the selection of beam angles (geometry problem), the computation of a fluence pattern for each selected beam angle (intensity problem), and finding a sequence of configurations of a multilef collimator to deliver the treatment (realization problem). While many mathematical optimization models and algorithms have been proposed for the intensity problem and (to a lesser extent) the realization problem, this is not the case for the geometry problem. In clinical practice, beam directions are manually selected by a clinician and are typically based on the clinician’s experience. Solving the beam selection problem optimally is …