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A Poisson-Like Model Of Sub-Clinical Signs From The Examination Of Healthy Aging Subjects, Stephen Merrill, Barbara Myklebust, Joel B. Myklebust, Norman Reynolds, Edmund Duthie
A Poisson-Like Model Of Sub-Clinical Signs From The Examination Of Healthy Aging Subjects, Stephen Merrill, Barbara Myklebust, Joel B. Myklebust, Norman Reynolds, Edmund Duthie
Mathematics, Statistics and Computer Science Faculty Research and Publications
Background and aims: Our studies of the standard neurological examination on 66 middle-aged (50–64 yrs) and elderly subjects (65–84 yrs) demonstrate that healthy elders have neurological deficits (or “signs”) that are not associated with specific known neurological disease. The purpose of the current study is to describe this loss of neurological function in healthy aging subjects as seen through accumulated subclinical neurological signs present.
Methods: Logistic regression is applied to the data on each of six signs. Parameters determined are used to describe the distribution of first occurrence times for each sign. The results are then used to construct a …