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Full-Text Articles in Mathematics

Intensity-Based Skeletonization Of Cryoem Gray-Scale Images Using A True Segmentation-Free Algorithm, Kamal Al Nasr, Chunmei Liu, Mugizi Rwebangira, Legand Burge, Jing He Jan 2013

Intensity-Based Skeletonization Of Cryoem Gray-Scale Images Using A True Segmentation-Free Algorithm, Kamal Al Nasr, Chunmei Liu, Mugizi Rwebangira, Legand Burge, Jing He

Computer Science Faculty Publications

Cryo-electron microscopy is an experimental technique that is able to produce 3D gray-scale images of protein molecules. In contrast to other experimental techniques, cryo-electron microscopy is capable of visualizing large molecular complexes such as viruses and ribosomes. At medium resolution, the positions of the atoms are not visible and the process cannot proceed. The medium-resolution images produced by cryo-electron microscopy are used to derive the atomic structure of the proteins in de novo modeling. The skeletons of the 3D gray-scale images are used to interpret important information that is helpful in de novo modeling. Unfortunately, not all features of the …


A Method Based On Total Variation For Network Modularity Optimization Using The Mbo Scheme, Huiyi Hu, Thomas Laurent, Mason A. Porter, Andrea L. Bertozzi Jan 2013

A Method Based On Total Variation For Network Modularity Optimization Using The Mbo Scheme, Huiyi Hu, Thomas Laurent, Mason A. Porter, Andrea L. Bertozzi

Mathematics, Statistics and Data Science Faculty Works

The study of network structure is pervasive in sociology, biology, computer science, and many other disciplines. One of the most important areas of network science is the algorithmic detection of cohesive groups of nodes called “communities.” One popular approach to finding communities is to maximize a quality function known as modularity to achieve some sort of optimal clustering of nodes. In this paper, we interpret the modularity function from a novel perspective: we reformulate modularity optimization as a minimization problem of an energy functional that consists of a total variation term and an $\ell_2$ balance term. By employing numerical techniques …