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Prediction Of Mrna Polyadenylation Sites In The Human Genome And Mathematical Modeling Of Alternative Polyadenylation, Yiming Cheng
Prediction Of Mrna Polyadenylation Sites In The Human Genome And Mathematical Modeling Of Alternative Polyadenylation, Yiming Cheng
Dissertations
Messenger RNA (mRNA) polyadenylation plays many important roles in the cell, such as transcription termination, mRNA stability and transportation, and mRNA translation in eukaryotic cells. A large number of human and mouse genes have multiple polyadenylation sites (referred to as poly(A) sites) that lead to variable transcripts, some of which are translated into various protein products with different functions. However, the details about when and where the polyadenylation occurs, and how pre-mRNA switches from one poly(A) site to another are still unknown. This kind of 3 '-end processing can be regulated by the cell environment, cell cycle stage, and tissue …