Mathematics Commons^™

Seeking Bang-Bang Solutions Of Mixed Immuno-Chemotherapy Of Tumors, Lisette G. De Pillis, K Renee Fister, Weiqing Gu, Craig Collins, Michael Daub, David Gross '08, James Moore '07, Benjamin Preskill '09

All HMC Faculty Publications and Research

It is known that a beneficial cancer treatment approach for a single patient often involves the administration of more than one type of therapy. The question of how best to combine multiple cancer therapies, however, is still open. In this study, we investigate the theoretical interaction of three treatment types (two biological therapies and one chemotherapy) with a growing cancer, and present an analysis of an optimal control strategy for administering all three therapies in combination. In the situations with controls introduced linearly, we find that there are conditions on which the controls exist singularly. Although bang-bang controls (on-off) reflect …