Mathematics Commons^™

Functional Implications Of Dale's Law In Balanced Neuronal Network Dynamics And Decision Making, Victor J. Barranca, Asha Bhuiyan , '23, Max Sundgren , '22, Fangzhou Xing , '22

Mathematics & Statistics Faculty Works

The notion that a neuron transmits the same set of neurotransmitters at all of its post-synaptic connections, typically known as Dale's law, is well supported throughout the majority of the brain and is assumed in almost all theoretical studies investigating the mechanisms for computation in neuronal networks. Dale's law has numerous functional implications in fundamental sensory processing and decision-making tasks, and it plays a key role in the current understanding of the structure-function relationship in the brain. However, since exceptions to Dale's law have been discovered for certain neurons and because other biological systems with complex network structure incorporate individual …