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Statistical Methods For Differential Gene Expression Analysis Under The Case-Cohort Design, Lidong Wang
Statistical Methods For Differential Gene Expression Analysis Under The Case-Cohort Design, Lidong Wang
Mathematics & Statistics ETDs
Differential gene expression analysis has the potential to discover candidate biomarkers, therapeutic targets, and gene signatures. How to save money when using an unaffordable sample is a practical question. The case-cohort (CCH) study design can blend the economy of case-control studies with the advantages of cohort studies. But it has not been seen in the medical research literature where high-throughput genomic data were involved.
A score test does not need to fit the Cox PH model iteratively; hence, it can save computing time and avoid potential convergence issues. We developed a score test under the CCH design to identify DEGs …