Mathematics Commons^™

A Comprehensive Uncertainty Quantification Methodology For Metrology Calibration And Method Comparison Problems Via Numeric Solutions To Maximum Likelihood Estimation And Parametric Bootstrapping, Aloka B. S. N. Dayarathne

All Graduate Theses and Dissertations, Fall 2023 to Present

In metrology, the science of measurements, straight line calibration models are frequently employed. These models help understand the instrumental response to an analyte, whose chemical constituents are unknown, and predict the analyte’s concentration in a sample. Techniques such as ordinary least squares and generalized least squares are commonly used to fit these calibration curves. However, these methods may yield biased estimates of slope and intercept when the calibrant, substance used to calibrate an analytical procedure with known chemical constituents (x-values), carries uncertainty. To address this, Ripley and Thompson (1987) proposed functional relationship estimation by maximum likelihood (FREML), which considers uncertainties …