Mathematics Commons^™

Analyzing Multiple-Probe Microarray: Estimation And Application Of Gene Expression Indexes, Mehdi Maadooliat, Jianhua Z. Huang, Jianhua Hu

Mathematics, Statistics and Computer Science Faculty Research and Publications

Gene expression index estimation is an essential step in analyzing multiple probe microarray data. Various modeling methods have been proposed in this area. Amidst all, a popular method proposed in Li and Wong (2001) is based on a multiplicative model, which is similar to the additive model discussed in Irizarry et al. (2003a) at the logarithm scale. Along this line, Hu et al. (2006) proposed data transformation to improve expression index estimation based on an ad hoc entropy criteria and naive grid search approach. In this work, we re-examined this problem using a new profile likelihood-based transformation estimation approach that …