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Theoretical Open-Loop Model Of Respiratory Mechanics In The Extremely Preterm Infant, Laura Ellwein Fix, Joseph Khoury, Russell R. Moores Jr., Lauren Linkous, Matthew Brandes, Henry J. Rozycki

Mathematics and Applied Mathematics Publications

Non-invasive ventilation is increasingly used for respiratory support in preterm infants, and is associated with a lower risk of chronic lung disease. However, this mode is often not successful in the extremely preterm infant in part due to their markedly increased chest wall compliance that does not provide enough structure against which the forces of inhalation can generate sufficient pressure. To address the continued challenge of studying treatments in this fragile population, we developed a nonlinear lumped-parameter respiratory system mechanics model of the extremely preterm infant that incorporates nonlinear lung and chest wall compliances and lung volume parameters tuned to …