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Sttructure-Function Correlations Of The Antagonist Effects Of Flavonoids Present In Medicinal Plants On Oxidative Reactive Molecules, Deema Khalil Al Jayousi

Theses

Flavonoids are phenolic compounds with significant antioxidant properties. The propensity of a flavonoid to inhibit free-radical mediated events is governed by its chemical structure. Since these compounds are based on the flavan nucleus, the number, positions, and types of substitutions influence radical scavenging and chelating activity. The main objective of this thesis was to establish structure-activity relationships of flavonoids by means of experimental and computational techniques.

Initially, a series of dietary flavonoids belonging to the most representative families (flavonols; myricetin, quercetin, morin, kaempferol, and 3-hydrxoyflavone, flavones; flavone and flavanones; naringenin) were studied during the reaction with DPPH radical following addition …