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Protection By 20-5,14-Hedge Against Surgically-Induced Ischemia Reperfusion Lung Injury In Rats, Irshad Ali, Stephanie Gruenloh, Ying Gao, Anne V. Clough, John R. Falck, Meetha Medhora, Elizabeth R. Jacobs
Protection By 20-5,14-Hedge Against Surgically-Induced Ischemia Reperfusion Lung Injury In Rats, Irshad Ali, Stephanie Gruenloh, Ying Gao, Anne V. Clough, John R. Falck, Meetha Medhora, Elizabeth R. Jacobs
Mathematics, Statistics and Computer Science Faculty Research and Publications
Background
We previously reported that the cytochrome P450 product 20-hydroxyeicosatetraenoic acid has prosurvival effects in pulmonary artery endothelial cells and ex vivo pulmonary arteries. We tested the potential of a 20-hydroxyeicosatetraenoic acid analog N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine (20-5,14-HEDGE) to protect against lung ischemic reperfusion injury in rats. Furthermore, we examined activation of innate immune system components, high mobility group box 1 (HMGB1) and toll-like receptor 4 (TLR4), in this model as well as the effect of 20-5,14-HEDGE on this signaling pathway.
Methods
Sprague-Dawley rats treated with 20-5,14-HEDGE or vehicle were subjected to surgically induced, unilateral lung ischemia for 60 minutes followed by reperfusion …