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Theses and Dissertations

2018

Machine Learning

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Full-Text Articles in Computer Sciences

Machine Learning For Inspired, Structured, Lyrical Music Composition, Paul Mark Bodily Jul 2018

Machine Learning For Inspired, Structured, Lyrical Music Composition, Paul Mark Bodily

Theses and Dissertations

Computational creativity has been called the "final frontier" of artificial intelligence due to the difficulty inherent in defining and implementing creativity in computational systems. Despite this difficulty computer creativity is becoming a more significant part of our everyday lives, in particular music. This is observed in the prevalence of music recommendation systems, co-creational music software packages, smart playlists, and procedurally-generated video games. Significant progress can be seen in the advances in industrial applications such as Spotify, Pandora, Apple Music, etc., but several problems persist. Of more general interest, however, is the question of whether or not computers can exhibit autonomous …


Machine Learning Based Disease Gene Identification And Mhc Immune Protein-Peptide Binding Prediction, Zhonghao Liu Jan 2018

Machine Learning Based Disease Gene Identification And Mhc Immune Protein-Peptide Binding Prediction, Zhonghao Liu

Theses and Dissertations

Machine learning and deep learning methods have been increasingly applied to solve challenging and important bioinformatics problems such as protein structure prediction, disease gene identification, and drug discovery. However, the performances of existing machine learning based predictive models are still not satisfactory. The question of how to exploit the specific properties of bioinformatics data and couple them with the unique capabilities of the learning algorithms remains elusive. In this dissertation, we propose advanced machine learning and deep learning algorithms to address two important problems: mislocation-related cancer gene identification and major histocompatibility complex-peptide binding affinity prediction. Our first contribution proposes a …