Computer Sciences Commons^™

Generalized Differentiable Neural Architecture Search With Performance And Stability Improvements, Emily J. Herron

Doctoral Dissertations

This work introduces improvements to the stability and generalizability of Cyclic DARTS (CDARTS). CDARTS is a Differentiable Architecture Search (DARTS)-based approach to neural architecture search (NAS) that uses a cyclic feedback mechanism to train search and evaluation networks concurrently, thereby optimizing the search process by enforcing that the networks produce similar outputs. However, the dissimilarity between the loss functions used by the evaluation networks during the search and retraining phases results in a search-phase evaluation network, a sub-optimal proxy for the final evaluation network utilized during retraining. ICDARTS, a revised algorithm that reformulates the search phase loss functions to ensure …

Generative Adversarial Game With Tailored Quantum Feature Maps For Enhanced Classification, Anais Sandra Nguemto Guiawa

Doctoral Dissertations

In the burgeoning field of quantum machine learning, the fusion of quantum computing and machine learning methodologies has sparked immense interest, particularly with the emergence of noisy intermediate-scale quantum (NISQ) devices. These devices hold the promise of achieving quantum advantage, but they grapple with limitations like constrained qubit counts, limited connectivity, operational noise, and a restricted set of operations. These challenges necessitate a strategic and deliberate approach to crafting effective quantum machine learning algorithms.

This dissertation revolves around an exploration of these challenges, presenting innovative strategies that tailor quantum algorithms and processes to seamlessly integrate with commercial quantum platforms. A …

A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb

Masters Theses

One of the biggest challenges the clinical research industry currently faces is the accurate forecasting of patient enrollment (namely if and when a clinical trial will achieve full enrollment), as the stochastic behavior of enrollment can significantly contribute to delays in the development of new drugs, increases in duration and costs of clinical trials, and the over- or under- estimation of clinical supply. This study proposes a Machine Learning model using a Fully Convolutional Network (FCN) that is trained on a dataset of 100,000 patient enrollment data points including patient age, patient gender, patient disease, investigational product, study phase, blinded …