Computer Sciences Commons^™

Machine Learning Based Disease Gene Identification And Mhc Immune Protein-Peptide Binding Prediction, Zhonghao Liu

Theses and Dissertations

Machine learning and deep learning methods have been increasingly applied to solve challenging and important bioinformatics problems such as protein structure prediction, disease gene identification, and drug discovery. However, the performances of existing machine learning based predictive models are still not satisfactory. The question of how to exploit the specific properties of bioinformatics data and couple them with the unique capabilities of the learning algorithms remains elusive. In this dissertation, we propose advanced machine learning and deep learning algorithms to address two important problems: mislocation-related cancer gene identification and major histocompatibility complex-peptide binding affinity prediction. Our first contribution proposes a …