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Medicine and Health Sciences

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Open Access Theses & Dissertations

Machine Learning

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Full-Text Articles in Computer Sciences

Development Of A Cost-Constrained Intelligent Prosthetic Knee With Real-Time Machine Learning, Predictive Stumble Control, Lucas Jonathan Galey May 2023

Development Of A Cost-Constrained Intelligent Prosthetic Knee With Real-Time Machine Learning, Predictive Stumble Control, Lucas Jonathan Galey

Open Access Theses & Dissertations

The field of biomechatronics is evolving quickly with advances in computer science, biology, and electrical and mechanical engineering. Coupled with increased interests in machine learning (ML) across all industry sectors, there are opportunities to leverage advanced analytics in uniquely complex problems. This study aimed to deploy real-time ML predictions in a novel microprocessor-controlled prosthetic knee (MPK) device capable of identifying and responding to stumble-events to reduce amputee fall prevalence. Innately, stumbling is a chaotic event. Current MPKs operate by detecting gait characteristics and reacting to preprogrammed states. While these systems are beneficial in significant ways, such as energy expenditure and …


Covid Synergy: A Machine Learning Approach Uncovering Potential Treatment Combinations For Sars-Cov-2, Jason Eden Sanchez May 2022

Covid Synergy: A Machine Learning Approach Uncovering Potential Treatment Combinations For Sars-Cov-2, Jason Eden Sanchez

Open Access Theses & Dissertations

For more than two years, the COVID-19 pandemic has upended the lives of billions of individualsworldwide leading to disruptions in healthcare, the economy and society at large. As the pandemic enters its third year, the human impact cannot be overstated and the need to develop effective pharmaceuticals remains. Though there currently exits FDA-approved medications for COVID-19, the emergence of novel variants, such as Omicron, highlights the importance of discovering new therapies which will continue to be effective regardless of the pandemicâ??s progression. Because discovering new medications is a costly and timeintensive endeavor, my approach entails drug repurposing to test medications …


Benchmarking Machine Learning Methods For Molecular Property Prediction, Govinda Bahadur Kc Jan 2020

Benchmarking Machine Learning Methods For Molecular Property Prediction, Govinda Bahadur Kc

Open Access Theses & Dissertations

Machine learning (ML) techniques have been widely applied in a variety of areas ranging from pattern recognition, natural language processing, and computer games to self-driving cars, clinical diagnostics, and molecular structure prediction easing day to day life of human beings. Drug discovery is an expensive, complex, and time taking process. Currently, the pharma industry is hoping to leverage machine learning methods in expediting the drug discovery process. Molecular property prediction is one of the most important tasks in drug discovery. While developing a new drug relies on a proper understanding of molecular properties, there has been great interest in the …