Chemistry Commons^™

Metabolism-Driven High-Throughput Cancer Identification With Glut5-Specific Molecular Probes, Srinivas Kannan, Vagarshak Begoyan, Joseph Fedie, Shuai Xia, Łukasz J. Weseliński, Marina Tanasova, Smitha Rao

Michigan Tech Publications

Point-of-care applications rely on biomedical sensors to enable rapid detection with high sensitivity and selectivity. Despite advances in sensor development, there are challenges in cancer diagnostics. Detection of biomarkers, cell receptors, circulating tumor cells, gene identification, and fluorescent tagging are time-consuming due to the sample preparation and response time involved. Here, we present a novel approach to target the enhanced metabolism in breast cancers for rapid detection using fluorescent imaging. Fluorescent analogs of fructose target the fructose-specific transporter GLUT5 in breast cancers and have limited to no response from normal cells. These analogs demonstrate a marked difference in adenocarcinoma and …