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Articles 1 - 11 of 11
Full-Text Articles in Chemistry
Thioenamide Synthesis Inspired By Peptide Macrocycles, Joshua Allen Lutz
Thioenamide Synthesis Inspired By Peptide Macrocycles, Joshua Allen Lutz
LSU Doctoral Dissertations
Despite advances in medicine, antibiotic resistance threatens to return once preventable diseases to the human population. The microbisporicins are 24-amino acid antibiotic peptides belonging to the lantibiotic class, which pathogens have been slow to develop resistance. The uncommon post-translational modification S-[(Z)-2-aminovinyl]-D-cysteine (AviCys) is likely crucial to their activity, and appears in a small number of other peptides with compelling biological activities. Total synthesis of an AviCys-containing peptide has eluded the chemical community.
The primary challenge of AviCys synthesis is the construction of a thioenamide functional group. We demonstrate that acid-promoted reactions between an amide and …
Organic Chemistry Ii Lab Manual, Caitlyn Bailey
Organic Chemistry Ii Lab Manual, Caitlyn Bailey
Senior Honors Theses
This project aims to supply a full lab manual and grading key for Organic Chemistry II, a class often taken by sophomores in Liberty University’s science degree programs. Properly applied laboratory experiments create a beneficial learning environment for science students by using hands-on procedures to transform intangible lecture concepts into concrete demonstrations. Lab work also fosters the development of problem-solving and critical-thinking skills that students need in research and the workplace. Thus, having a comprehensive lab manual is critical to students’ success and understanding in this upper-level class. This project adds to the experiments of Organic Chemistry II lab through …
Use Of Pope Engagement Index To Measure Cognitive Load Of Physical Modeling Activities In Organic Chemistry, Jenifer Calvert
Use Of Pope Engagement Index To Measure Cognitive Load Of Physical Modeling Activities In Organic Chemistry, Jenifer Calvert
Master of Science in Chemical Sciences Theses
Understanding how students learn and process information is critical to developing physical modeling activities that facilitate student learning by decreasing cognitive load in the working memory. Optimizing cognitive load during physical modeling activities in organic chemistry is the key to effective and efficient learning. Using EEG (electroencephalogram) and eye tracking technologies, researchers measured and recorded the cognitive processing of participants while they completed a chiral physical modeling activity. Analysis of the data using the Engagement Index developed by Pope et al provided information necessary to develop curriculum that does not undermine student learning due to excessive cognitive load.
Organic Chemistry With A Biological Emphasis Volume Ii, Timothy Soderberg
Organic Chemistry With A Biological Emphasis Volume Ii, Timothy Soderberg
Chemistry Publications
The traditional approach to teaching Organic Chemistry, taken by most of the textbooks that are currently available, is to focus primarily on the reactions of laboratory synthesis, with much less discussion - in the central chapters, at least - of biological molecules and reactions. This is despite the fact that, in many classrooms, a majority of students are majoring in Biology or Health Sciences rather than in Chemistry, and are presumably taking the course in order to learn about the chemistry that takes place in living things.
In an effort to address this disconnect, I have developed a textbook for …
Organic Chemistry With A Biological Emphasis Volume I, Timothy Soderberg
Organic Chemistry With A Biological Emphasis Volume I, Timothy Soderberg
Chemistry Publications
The traditional approach to teaching Organic Chemistry, taken by most of the textbooks that are currently available, is to focus primarily on the reactions of laboratory synthesis, with much less discussion - in the central chapters, at least - of biological molecules and reactions. This is despite the fact that, in many classrooms, a majority of students are majoring in Biology or Health Sciences rather than in Chemistry, and are presumably taking the course in order to learn about the chemistry that takes place in living things.
In an effort to address this disconnect, I have developed a textbook for …
Application Of The Picoloyl Substituent In Carbohydrate Chemistry, Michael Mannino, Alexei V. Demchenko
Application Of The Picoloyl Substituent In Carbohydrate Chemistry, Michael Mannino, Alexei V. Demchenko
Michael Mannino
Lewis Base Promoted Annulations Of Allenoates With 1,4-Naphthoquinones, Nicole Marie Shoup
Lewis Base Promoted Annulations Of Allenoates With 1,4-Naphthoquinones, Nicole Marie Shoup
Electronic Theses and Dissertations
Lewis base promoted cyclization of allenoates with electron deficient olefins open up the possibility to generate more complex organic structures. By generating more complex molecules, we are able to produce new compounds for biomedical and material applications. Both phosphine and amine Lewis bases offer interesting annulations with allenoates resulting in Lu or Morita–Baylis–Hillman type reactions. Once the Lewis base engages with the allenoate there can be several modes of nucleophilic reactivity that allows for the allenic ester to act as a two or three carbon synthon. The allenoate can then react with varying electron deficient olefins generating more complex molecules …
Synthesis And Conformational Studies Of Various Amides, Marcos Beltran-Sanchez
Synthesis And Conformational Studies Of Various Amides, Marcos Beltran-Sanchez
University of the Pacific Theses and Dissertations
In the past, aminocyclohexanol rings have been successfully utilized as pH-triggered molecular switches in various trans-2-aminocyclohexanol derivatives. By changing the groups on the amine nitrogen, these models provided a wide pH range in which a switch can occur. The pH-induced switch of conformation was monitored by 1H-NMR spectroscopy. The models were also incorporated into the bilayer membrane of liposome structures and tested for their ability to disrupt their membrane upon their conformational flip induced by a decrease in pH.
In this work, the amide bond has been studied as a molecular switch and various amide derivatives have been tested for …
Recent Trends In Stratospheric Chlorine From Very Short‐Lived Substances, Ryan Hossaini, Elliot Atlas, Sandip S. Dhomse, Martyn P. Chipperfield, Peter F. Bernath, Anton M. Fernando, Jens Mühle, Amber A. Leeson, Stephen A. Montzka, Wuhu Feng
Recent Trends In Stratospheric Chlorine From Very Short‐Lived Substances, Ryan Hossaini, Elliot Atlas, Sandip S. Dhomse, Martyn P. Chipperfield, Peter F. Bernath, Anton M. Fernando, Jens Mühle, Amber A. Leeson, Stephen A. Montzka, Wuhu Feng
Chemistry & Biochemistry Faculty Publications
Very short‐lived substances (VSLS), including dichloromethane (CH2Cl2), chloroform (CHCl3), perchloroethylene (C2Cl4), and 1,2‐dichloroethane (C2H4Cl2), are a stratospheric chlorine source and therefore contribute to ozone depletion. We quantify stratospheric chlorine trends from these VSLS (VSLCltot) using a chemical transport model and atmospheric measurements, including novel high‐altitude aircraft data from the NASA VIRGAS (2015) and POSIDON (2016) missions. We estimate VSLCltot increased from 69 (±14) parts per trillion (ppt) Cl in 2000 to 111 (±22) ppt Cl in 2017, with >80% delivered to …
Phosgene In The Upper Troposphere And Lower Stratosphere: A Marker For Product Gas Injection Due To Chlorine-Containing Very Short Lived Substances, Jeremy J. Harrison, Martyn P. Chipperfield, Ryan Hossaini, Christopher D. Boone, Sandip Dhomse, Wuhu Feng, Peter F. Bernath
Phosgene In The Upper Troposphere And Lower Stratosphere: A Marker For Product Gas Injection Due To Chlorine-Containing Very Short Lived Substances, Jeremy J. Harrison, Martyn P. Chipperfield, Ryan Hossaini, Christopher D. Boone, Sandip Dhomse, Wuhu Feng, Peter F. Bernath
Chemistry & Biochemistry Faculty Publications
Abstract: Phosgene in the atmosphere is produced via the degradation of carbon tetrachloride, methyl chloroform, and a number of chlorine‐containing very short lived substances (VSLS). These VSLS are not regulated by the Montreal Protocol even though they contribute to stratospheric ozone depletion. While observations of VSLS can quantify direct stratospheric source gas injection, observations of phosgene in the upper troposphere/lower stratosphere can be used as a marker of product gas injection of chlorine‐containing VSLS. In this work we report upper troposphere/lower stratosphere measurements of phosgene made by the ACE‐FTS (Atmospheric Chemistry Experiment Fourier Transform Spectrometer) instrument and compare with results …
Near-Infrared High Efficiency Organic Dye Sensitized Solar Cells (Dscs) And Biological Fluorescent Imaging Dyes, Yanbing Zhang
Near-Infrared High Efficiency Organic Dye Sensitized Solar Cells (Dscs) And Biological Fluorescent Imaging Dyes, Yanbing Zhang
Electronic Theses and Dissertations
With the energy consumption increase every year, the non-renewable energy sources such as fossil fuels, natural gas, and coal will not sustain forever. In this case, searching for a way to develop a renewable energy source is an emergency. For decades, dye-sensitized solar cells (DSCs) have received intensive attention due to their high power conversion efficiency and low material cost. This dissertation describes efforts to design and synthesize near-infrared organic dyes to apply to two systems: first, for use in the improvement of DSCs by the optimization of electron rich components such as ullazine and cross-conjugated -bridges to increase photon-to-electricity …