Chemistry Commons^™

The Roles Of Silanes As Coupling Reagents And In Deoxygenative Alkylations, Andrea S. Dupre

LSU Master's Theses

Silane reagents play important roles in many areas of organic synthesis. This is primarily due to the ability of silanes to bond to more ligands than the traditional four to become hypervalent (i.e. penta- or hexavalent). This hypervalency causes the silicon center to become more Lewis Acidic and causes the formation of carbon nucleophiles from organosilane ligands. These nucleophiles have been used to perform many cross-coupling reactions with organohalide reagents. The research presented in this thesis reports the utility of silane reagents in cross-coupling reactions of Grignard reagents with alkyl halides. This cross coupling was desirable because the silane should …