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Articles 1 - 30 of 39
Full-Text Articles in Chemistry
Effect Of A Strategically Positioned Methoxy Substituent On The Photochemistry Of 3-Aryl-3h-1-Oxacyclopenta[L]Phenanthren-2-Ones, Roshini Thumpakara, Binoy Jose, Perupparampil Unnikrishnan, Sreedharan Prathapan, Nigam Rath
Effect Of A Strategically Positioned Methoxy Substituent On The Photochemistry Of 3-Aryl-3h-1-Oxacyclopenta[L]Phenanthren-2-Ones, Roshini Thumpakara, Binoy Jose, Perupparampil Unnikrishnan, Sreedharan Prathapan, Nigam Rath
Chemistry & Biochemistry Faculty Works
Irradiation of 3-methoxy-3-aryl-3H-1-oxacyclopenta[l]phenanthren-2-one derivatives 5a–d resulted in singlet-mediated decarbonylation reaction leading to the formation of phenanthrene derivatives 9a–d. The structure of the photoproduct was unequivocally established on the basis of X-ray crystallographic analysis.
Two-Phase Partitioning System Using Elvax 40w Polymer For The Biodegradation Of Aqueous Phenols, Amit Suresh Ghode
Two-Phase Partitioning System Using Elvax 40w Polymer For The Biodegradation Of Aqueous Phenols, Amit Suresh Ghode
Masters Theses & Specialist Projects
A solid-liquid two phase partitioning system (TPPS) is a new technology platform for destroying toxic organic compounds. TPPS have traditionally been operated by using an immiscible organic phase which partitions organic compounds into the aqueous phase. TPPS using an immiscible organic phase suffers from several limitations such as the organic phase could be biodegradable and hence only certain compatible microbial strains could be used. This therefore, eliminates the desired use of mixed microbial populations for efficient degradation. A solid-liquid two phase partitioning system, in which solid polymeric beads replace liquid organic phase, appears to have benefits over the traditional liquid-liquid …
Investigation Of Volatile Products From Wood Pyrolysis, Prabhavathi Gade
Investigation Of Volatile Products From Wood Pyrolysis, Prabhavathi Gade
Masters Theses & Specialist Projects
In this research we are following the thermo-chemical degradation of wood in the absence of oxygen. The objectives are to evaluate the influence of heating rates on pyrolysis products obtained from wood pyrolysis and to evaluate the influence of acid pre-treatment on pyrolysis products. Depending on the wood heating rates, pyrolysis can be categorized as Flash pyrolysis, Fast pyrolysis, and Slow pyrolysis. We have evaluated the volatile products obtained at different heating rates and the volatile products obtained from sulfuric acid pre-treatment by using gas chromatography- mass spectrometry (GC-MS). We have also performed thermo-gravimetric analysis (TGA) of raw wood samples …
Iota-Carrageenan Hydrolysis By Pseudoalteromonas Carrageenovora Ifo12985, Bernadette M. Henares, Erwin P. Enriquez, Fabian M. Dayrit, Nina Rosario L. Rojas
Iota-Carrageenan Hydrolysis By Pseudoalteromonas Carrageenovora Ifo12985, Bernadette M. Henares, Erwin P. Enriquez, Fabian M. Dayrit, Nina Rosario L. Rojas
Chemistry Faculty Publications
We report iota-carrageenan hydrolysis by Pseudoalteromonas carrageenovora IFO 12985. Kappa-carrageenase and lambda-carrageenase were previously isolated from this organism, but iota-carrageenase activity had not been reported in the literature. P. carrageenovora was grown in iota-carrageenan-based liquid medium. Using the zone of depression assay, transfer of aliquots of the culture to solid medium with 2% iota- and kappa-carrageenan showed extensive hydrolysis of iota-carrageenan. Analysis of the hydrolysates by C-13 Nuclear Magnetic Resonance spectroscopy confirmed degradation of the iota-carrageenan. Hydrolytic activity of P. carrageenovora grown in iota-carrageenan was compared with that of the same organism grown in kappa-carrageenan. Cell-free supernatants from each yielded …
Ultrasonic Activation Of Triacetone Triperoxide, Latravia R. Dobson
Ultrasonic Activation Of Triacetone Triperoxide, Latravia R. Dobson
Department of Chemistry: Dissertations, Theses, and Student Research
Triacetone triperoxide (TATP) is an organic peroxide that has received widespread attention in recent years. TATP is a ketone peroxide with a high active oxygen content. It is relatively shock sensitive, with explosive decomposition easily initiated, and is therefore considered a primary explosive. However, TATP is also a powerful explosive possessing about 83 % of the power of TNT. TATP can be prepared quickly and easily from inexpensive household chemicals in the absence of any specialized facilities, making it the explosive of choice for modern day terrorists.
TATP poses a major challenge for security and law enforcement services around the …
I. A New Synthetic Approach To The Synthesis Of N-(Phosphonoacetyl)-L-Ornithine, Ii. The Influence Of Pyridine On The Ozonolysis Of Alkenes, Bradley M. Johnson
I. A New Synthetic Approach To The Synthesis Of N-(Phosphonoacetyl)-L-Ornithine, Ii. The Influence Of Pyridine On The Ozonolysis Of Alkenes, Bradley M. Johnson
Department of Chemistry: Dissertations, Theses, and Student Research
Part I. The use of chemical inhibitors to manipulate the level of amino acids in cells has proven to be invaluable in the mechanistic study of gene expression in bacteria and fungi. Here we present a new approach to the synthesis of δ‐N‐ (phosphonoacetyl)‐L‐ornithine (PALO), a potent ornithine transcarbamylase inhibitor, using a new amino acid protecting group, 9‐borabicyclononane (9‐BBN). Starting from commercially available reagents and utilizing mild reaction conditions, we were able to form PALO in fewer synthetic steps and in greater yields than previous attempts.
Part II. Ozonolysis is widely used to transform alkenes into oxygen‐rich functional groups (e.g.– …
Biomimetic Modeling Of The Nitrogen-Centered Radical Postulated To Occur During The Inhibition Of Ribonucleotide Reductases By 2'-Azido-2'-Deoxynucleotides., Thao P. Dang
FIU Electronic Theses and Dissertations
Ribonucleotide reductases (RNR) are essential enzymes that catalyze the reduction of ribonucleotides to 2'-deoxyribonucleotides, which is a critical step that produces precursors for DNA replication and repair. The inactivation of RNR, logically, would discontinue producing the precursors of the DNA of viral or cancer cells, which then would consequently end the cycle of DNA replication. Among different compounds that were found to be inhibitors of RNR, 2'-azido-2'-deoxynucleotide diphosphates (N3NDPs) have been investigated in depth as potent inhibitors of RNR. Decades of investigation has suggested that the inactivation of RNR by N3NDPs is a result of the formation of a nitrogen-centered …
(1e,3e)-1,4-Bis(4-Methoxyphenyl)Buta1,3-Diene, Gopinathan Narayan, Nigam Rath, Suresh Das
(1e,3e)-1,4-Bis(4-Methoxyphenyl)Buta1,3-Diene, Gopinathan Narayan, Nigam Rath, Suresh Das
Chemistry & Biochemistry Faculty Works
The title compound, C18H18O2, which exhibits blue emission in the solid state, is an intermediate in the preparation of liquid crystals and polymers. The molecule is located on an inversion centre. In the crystal, molecules are arranged in a herringbone motif.
Oga Inhibition By Glcnac-Selenazoline, E. J. Kim, D. C. Love, E. Darout, M. Abdo, B. Rempel, S. G. Withers, Paul R. Rablen, J. A. Hanover, S. Knapp
Oga Inhibition By Glcnac-Selenazoline, E. J. Kim, D. C. Love, E. Darout, M. Abdo, B. Rempel, S. G. Withers, Paul R. Rablen, J. A. Hanover, S. Knapp
Chemistry & Biochemistry Faculty Works
The title compound, which differs from the powerful O-GlcNAcase (OGA) inhibitor GlcNAc-thiazoline only at the chalcogen atom (Se for S), is a much weaker inhibitor in a direct OGA assay. In human cells, however, the selenazoline shows comparable ability to induce hyper-O-GlcNAc-ylation, and the two show similar reduction of insulin-stimulated translocation of glucose transporter 4 in differentiated 3T3 adipocytes. (C) 2010 Elsevier Ltd. All rights reserved.
4-PhenylSulfonYl-2-(P-TolylSulfonYl)-1h,8h-Pyrrolo[2,3-B]Indole, Jeanese C. Badenock, Jason A. Jordan, Erin T. Pelkey, Gordon W. Gribble, Jerry P. Jasinski
4-PhenylSulfonYl-2-(P-TolylSulfonYl)-1h,8h-Pyrrolo[2,3-B]Indole, Jeanese C. Badenock, Jason A. Jordan, Erin T. Pelkey, Gordon W. Gribble, Jerry P. Jasinski
Dartmouth Scholarship
The title compound, C23H18N2O4S2, contains a pyrrolo group fused onto the plane of an indole ring with phenylsulfonyl and p-toluenesulfonyl groups bonded to the indole and pyrrolo rings. The angles between the mean planes of the pyrrolo- indole ring and the phenylsulfonyl and p-toluenesulfonyl rings are 73.7 (6) and 80.6 (0), respectively. The dihedral angle between the mean planes of the two benzene rings is 78.7 (4). In the crystal, both classical N—H O and non-classical C— H O intermolecular hydrogen-bonding interactions are observed, as well as weak – interactions [centroid–centroid distances = 3.6258 (8) and 3.9298 (8) …
Jahn-Teller Coupling And Fragmentation After Core-Shell Excitation Ini Cf4 Investigated By Partial-Ion-Yield Spectroscopy, Renaud Guillemin, Wayne C. Stolte, Maria Novella Piancastelli, Dennis W. Lindle
Jahn-Teller Coupling And Fragmentation After Core-Shell Excitation Ini Cf4 Investigated By Partial-Ion-Yield Spectroscopy, Renaud Guillemin, Wayne C. Stolte, Maria Novella Piancastelli, Dennis W. Lindle
Chemistry and Biochemistry Faculty Research
We investigate fragmentation processes induced by core-level photoexcitation in CF4 at both the carbon and fluorine K edges by means of partial-ion-yield spectroscopy. The molecule CF4 is a textbook example of systems in which Jahn-Teller coupling strongly manifests itself in the photoabsorption spectrum. Spectral features related to Jahn-Teller and quasi-Jahn-Teller splitting are observed, and important differences in the fragmentation pathways are revealed depending on the symmetries of the core-excited states. We interpret these experimental observations on the grounds of symmetry lowering from the Td to the C3v point group as well as preferential orientation with respect …
I. Development Of The In Situ Reductive Ozonolysis Of Alkenes With Tertiary Amine N-Oxides. Ii. Progress Toward The Asymmetric Synthesis Of Peroxyplakoric Acid A3., Christopher P. Schwartz
I. Development Of The In Situ Reductive Ozonolysis Of Alkenes With Tertiary Amine N-Oxides. Ii. Progress Toward The Asymmetric Synthesis Of Peroxyplakoric Acid A3., Christopher P. Schwartz
Department of Chemistry: Dissertations, Theses, and Student Research
Ozone, first discovered in the mid 1800’s, is a triatomic allotrope of oxygen that is a powerful oxidant. For over a century, research has been conducted into the synthetic application and mechanism of reactions of ozone with organic compounds. One of the major areas of interest has been the ozonolysis of alkenes. The production of carbonyl compounds is the most common synthetic application of ozonolysis. The generally accepted mechanism developed by Rudolf Criegee for this reaction involves the 1,3-electrocyclic addition of ozone to the π bond of the alkene to form a 1,2,3-trioxolane or primary ozonide. The primary ozonide is …
Acetic Acid Aldol Reactions In The Presence Of Trimethylsilyl Trifluoromethanesulfonate, C. Wade Downey, Miles W. Johnson, Daniel H. Lawrence, Alan S. Fleisher, Kathryn J. Tracy
Acetic Acid Aldol Reactions In The Presence Of Trimethylsilyl Trifluoromethanesulfonate, C. Wade Downey, Miles W. Johnson, Daniel H. Lawrence, Alan S. Fleisher, Kathryn J. Tracy
Chemistry Faculty Publications
In the presence of TMSOTf and a trialkylamine base, acetic acid undergoes aldol addition to non-enolizable aldehydes under exceptionally mild conditions. Acidic workup yields the β-hydroxy carboxylic acid. The reaction appears to proceed via a three-step, one-pot process, including in situ trimethylsilyl ester formation, bis-silyl ketene acetal formation, and TMSOTf-catalyzed Mukaiyama aldol addition. Independently synthesized TMSOAc also undergoes aldol additions under similar conditions.
Molecular Orbitals And Organic Chemical Reactions (Book Review), Jeffrey H. Glans
Molecular Orbitals And Organic Chemical Reactions (Book Review), Jeffrey H. Glans
Chemistry & Physics Faculty Publications
Book review by Jeffrey Glans.
Fleming, Ian. Molecular Orbitals and Organic Chemical Reactions. Wiley-Blackwell, 2010, c2009.
ISBN: 9780470746608; 9780470746592 (pbk.)
Photoreactive Crystalline Quasiracemates, Rebecca C. Grove, Steven H. Malehorn, Meghan E. Breen, Kraig A. Wheeler
Photoreactive Crystalline Quasiracemates, Rebecca C. Grove, Steven H. Malehorn, Meghan E. Breen, Kraig A. Wheeler
Faculty Research and Creative Activity
Rationally designed racemic and quasiracemic sulfonamidecinnamic acids assemble to give hydrogen-bonded dimers with coplanar alignment of neighboring olefins. The quasiracemate phase contains near inversion-related motifs with chemically distinct components forming supramolecular heterodimers that undergo asymmetric photodimerization.
Synthesis, Kinetic And Photocatalytic Studies Of Porphyrin-Ruthenium-Oxo Complexes, Yan Huang
Synthesis, Kinetic And Photocatalytic Studies Of Porphyrin-Ruthenium-Oxo Complexes, Yan Huang
Masters Theses & Specialist Projects
Macrocyclic ligand-complexed transition metal-oxo intermediates are the active oxidizing species in a variety of important biological and catalytic oxidation reactions. Many transition metal catalysts have been designed to mimic the predominant oxidation catalysts in Nature, namely the cytochrome P450 enzymes. Ruthenium porphyrin complexes have been the center of the research and have successfully been utilized, as catalysts, in major oxidation reactions such as the hydroxylation of alkanes. This study focuses on kinetic and photocatalytic studies of oxidation reactions with wellcharacterized high-valent ruthenium-oxo porphyrin complexes.
The trans-dioxoruthenium(VI) porphyrins have been among the best characterized metal-oxo intermediates and their involvement as …
On-Metal Synthesis Of Some Aryl Substituted Rhenium Η5 Cyclopenta[C] Pyridazyl Complexes, Phenahas Gandu Sriramulu
On-Metal Synthesis Of Some Aryl Substituted Rhenium Η5 Cyclopenta[C] Pyridazyl Complexes, Phenahas Gandu Sriramulu
Masters Theses & Specialist Projects
Heterocyclic organic and organometallic compounds (e.g. polypyrrole) and their derivatives have been of great interest for conductive polymers due to their novel properties and environmental stability as compared to non-aromatic analogs (e.g. polyacetylene). We are interested in synthesizing organometallic pyridazines and rhenium pyridazyl complexes for polymer research. SeveraI5,6-fused ring pyridazines (1,2-CsH3(CRNH)(CRN) have been synthesized and characterized. Additionally, pyridazyl complexes of rhenium were synthesized in three steps beginning from fulvenes 1,2-CsH3(COHR)(COR). On-Metal synthesis and characterization of (Re(CO)3 {1,2- CSH3(CRN)(CRN)}] (R=C6RtOMe, C6RtCI, C4H30) and some off-metal pyridazines are reported here. Our research is focused on synthesis of a variety of 5,6- fused …
Controlling Reductive Elimination From Novel I(Iii) Salts Using A Secure Method, Joseph W. Graskemper
Controlling Reductive Elimination From Novel I(Iii) Salts Using A Secure Method, Joseph W. Graskemper
Department of Chemistry: Dissertations, Theses, and Student Research
Positron Emission Tomography (PET) is a valuable clinical, research, and diagnostic technique for human and animal organ imaging. The current market for PET in the United States is $500 million per year and is projected to be $5.4 billion per year globally by 2015. To synthesize labeled radiotracers, we are most interested in using 18F as the isotope of choice because it is a nearly ideal positron emitting radionuclide.
Electron-rich aromatic substrates can be particularly difficult to fluorinate. We show that reductive elimination of I(III) diaryliodonium salts provide increased fluorination of electron-rich aromatic substrates. Modest yields of fluorinated product …
Developing Of Germyldesulonylation And Thiodesulfonylation Reactions For The Synthesis Of Novel Nucleoside Analogues. Efficient Synthesis Of Novel (Α-Fluoro)Vinyl Sulfides, Pablo R. Sacasa Jr
Developing Of Germyldesulonylation And Thiodesulfonylation Reactions For The Synthesis Of Novel Nucleoside Analogues. Efficient Synthesis Of Novel (Α-Fluoro)Vinyl Sulfides, Pablo R. Sacasa Jr
FIU Electronic Theses and Dissertations
S-adenosyl-L-homocysteine (AdoHcy) hydrolase effects hydrolytic cleavage of AdoHcy to produce both adenosine and L-homocysteine and is a feedback inhibitor of S-adenosyl-L-methionine (SAM). Nucleoside analogues bearing an alkenyl or fluoroalkenyl chain between sulfur and C5′ utilizing Negishi coupling reactions were synthesized. Palladium-catalyzed cross-coupling between the 5′-deoxy-5′-(iodomethylene) nucleosides and alkylzinc bromides gives analogues with the alkenyl unit. Palladium-catalyzed selective monoalkylation of 5′-(bromofluoromethylene)-5′-deoxy-adenosine with alkylzinc bromide afford adenosylhomocysteine analogues with a 6′-(fluoro)vinyl motif. The vinylic adenine nucleosides produced time-dependent inactivation of the S-adenosyl-L-homocysteine hydrolases. Stannydesulfonylation reaction is a critical step in the synthesis of E-fluorovinyl cytidine (Tezacitabine) a ribonucleoside reductase inhibitor with a …
2,4,6-TriphenylAniline, Onome Ugono, Stephanie Cowin, Alicia Beatty
2,4,6-TriphenylAniline, Onome Ugono, Stephanie Cowin, Alicia Beatty
Chemistry & Biochemistry Faculty Works
Individual molecules of the title compound, C24H19N, do not participate in hydrogen-bonding interactions due to the steric bulk of the phenyl rings ortho to the amine. The dihedral angles between the central ring and the pendant rings are 68.26 (10), 55.28 (10) and 30.61 (11)°.
Rhodium-Catalyzed Hydroboration: Directed Asymmetric Desymmetrization, Judy L. Miska
Rhodium-Catalyzed Hydroboration: Directed Asymmetric Desymmetrization, Judy L. Miska
Department of Chemistry: Dissertations, Theses, and Student Research
Rhodium-catalyzed asymmetric hydroboration in conjunction with directing groups can be used control relative and absolute stereochemistry. Hydroboration has the potential to create new C–C, C–O, and C–N bonds from an intermediate C–B bond with retention of stereochemistry. Desymmetrization resulting in the loss of one or more symmetry elements can give rise to molecular chirality, i.e., the conversion of a prochiral molecule to one that is chiral. Unsaturated amides and esters hold the potential for two-point binding to the rhodium catalyst and have been shown to direct the regiochemistry and impact stereochemistry in asymmetric hydroborations of acyclic β,γ-unsaturated substrates. In …
Degradation Of Chlorophenols In Swine Waste, Srilatha Gangula
Degradation Of Chlorophenols In Swine Waste, Srilatha Gangula
Masters Theses & Specialist Projects
Naturally occurring plant derived phenols can be degraded through bacteria in swine waste. Chlorinated phenols, which are not naturally present in the environment, are toxic and generated from industrial activities as such petrochemical, pharmaceutical, plastic, rubber, pesticide, iron, steel, paper production, coal conversion, wood preserving, and cellulose bleaching. Large scale coal gasification and carbonization plants are another source of chlorinated phenols. Although not normally present in the environment, chlorinated phenols are structurally similar to many plant derived phenolics.
It is our hypothesis that bacteria located in swine wastes may also have the ability to degrade chlorinated phenols. Identifying situations (and …
New Chiral Phosphoramidite Complexes Of Iron As Catalytic Precursors In The Oxidation Of Activated Methylene Groups, Pushkar Shejwalkar, Nigam Rath, Eike Bauer
New Chiral Phosphoramidite Complexes Of Iron As Catalytic Precursors In The Oxidation Of Activated Methylene Groups, Pushkar Shejwalkar, Nigam Rath, Eike Bauer
Chemistry & Biochemistry Faculty Works
New phosphoramidite complexes of iron were synthesized and structurally characterized. Reaction of the known chiral phosphoramidites (RO)2PNR’2 (R = binaphthyl, R’ = CH3, 1a; R = binaphthyl, R’ = benzyl, 1b) with [FeBr(Cp)(CO)2] afforded the title compounds [FeBr(Cp)(CO)(1a,b)] (4a,b) in 34 and 65 % isolated yields as mixtures of diastereomers, since both the metal and the ligand are stereogenic. Similarly, reaction of 1b with [Fe(Cp)I(CO)2] in the presence of catalytic [Fe(Cp)(CO)2]2 afforded [Fe(Cp)I(CO)(1b)] (5b) in 81% yield as a mixture of diastereomers. The molecular structures of 4a, 4b and 5 were determined, revealing a pseudo octahedral coordination geometry about the …
Herbicides And Amphibian Populations, Zach Shirk
Herbicides And Amphibian Populations, Zach Shirk
Department of Environmental Studies: Undergraduate Student Theses
Amphibians are a unique class of species that are found worldwide except Antarctica and Greenland. They range in size from a few millimeters to over six feet long. Amphibian’s habitats are as various as their size, but one thing in common is that amphibians require an aquatic location to breed. Amphibians live in deserts, mountain prairies, rain forest, wetlands, and almost everywhere in between. Amphibians are an integrated part of most natural ecosystems across the world. Amphibians are a critical part of many food chains; they provide the important link between secondary and tertiary consumers. Amphibians are indicator species in …
Relatin Dissolved Oxygen Concentration To Fish Distribution In Jarecki Lake, Adam Sutton
Relatin Dissolved Oxygen Concentration To Fish Distribution In Jarecki Lake, Adam Sutton
Department of Environmental Studies: Undergraduate Student Theses
Abstract Water temperature and dissolved oxygen (DO) profiles were measured once every month from mid July to mid February in a relatively deep sand-pit lake in southeast Nebraska. These profiles showed depleted DO concentrations below the thermocline during summer stratification indicating areas fish will likely avoid in summer months. Colder temperatures in fall caused complete mixing of the water column allowing fish to inhabit all depths of the lake. An inverse temperature stratification occurred directly below the ice during winter months as ice cover cooled the surface water to below 4 degrees Celsius. Ice cover also blocked air – water …
Functionalization Of Aromatic Organic Molecules By Anhydrous Flourides And By Reductive Elimination Of Iodine(Iii), Bijia Wang
Department of Chemistry: Dissertations, Theses, and Student Research
Solution phase reactivity of nucleophilic fluoride reagents is attenuated by ion-pairing interactions. 1H-19F HOESY competition experiments permit generation of a fluoride ion affinity scale in the weak-binding regime. Direct DFT calculations of ion pair interaction energies as well as calculated cation electrostatic potential maps can be used to predict solution phase ion pairing tendencies for closely related ammonium cations. It was found by studying the decomposition of tetra-substituted ammonium cations by fluoride that: 1) rates of E2 decomposition is faster than the SN2 pathway; 2) aryl substituents destabilize the cations; 3) steric strain tends to …
A Novel Choline Cotransporter Sequestration Compartment In Cholinergic Neurons Revealed By Selective Endosomal Ablation, Michael T. Ivy, Robert F. Newkirk, Yilun Wang, James G. Townsel
A Novel Choline Cotransporter Sequestration Compartment In Cholinergic Neurons Revealed By Selective Endosomal Ablation, Michael T. Ivy, Robert F. Newkirk, Yilun Wang, James G. Townsel
Biology Faculty Research
The sodium-dependent, high affinity choline transporter – choline cotransporter – (ChCoT, aka: cho-1, CHT1, CHT) undergoes constitutive and regulated trafficking between the plasma membrane and cytoplasmic compartments. The pathways and regulatory mechanisms of this trafficking are not well understood. We report herein studies involving selective endosomal ablation to further our understanding of the trafficking of the ChCoT. Selective ablation of early sorting and recycling endosomes resulted in a decrease of ∼75% of [3H]choline uptake and ∼70% of [3H]hemicholinium-3 binding. Western blot analysis showed that ablation produced a similar decrease in ChCoTs in the plasma membrane subcellular fraction. The time frame …
Technology For The Organic Chemist: Three Exploratory Modules, John J. Esteb, Luanne M. Mcnulty, John Magers, Paul Morgan
Technology For The Organic Chemist: Three Exploratory Modules, John J. Esteb, Luanne M. Mcnulty, John Magers, Paul Morgan
Scholarship and Professional Work - LAS
The ability to use computer-based technology is an essential skill set for students majoring in chemistry. This exercise details the introduction of appropriate uses for this technology in the organic chemistry series. The incorporation of chemically appropriate online resources (module 1), scientific databases (module 2), and the use of a chemical drawing program (module 3) are detailed here.
A Mild And Chemoselective Method For The Deprotection Of Tert-Butyldimethylsilyl (Tbdms) Ethers Using Iron(Iii) Tosylate As A Catalyst, Ram Mohan, Jason Bothwell, Veronica Angeles, James Carolan, Margaret Olson
A Mild And Chemoselective Method For The Deprotection Of Tert-Butyldimethylsilyl (Tbdms) Ethers Using Iron(Iii) Tosylate As A Catalyst, Ram Mohan, Jason Bothwell, Veronica Angeles, James Carolan, Margaret Olson
Scholarship
The most common method for the deprotection ofTBDMS ethers utilizes stoichiometric amounts of tetrabutylammonium fluoride, n-Bu4N+F(TBAF), which is highly corrosive and toxic. We have developed a mild and chemoselective method for the deprotection ofTBDMS, TES, and TIPS ethers using iron(III) tosylate as a catalyst. Phenolic TBDMS ethers, TBDPS ethers and the BOC group are not affected under these conditions. Iron(III) tosylate is an inexpensive, commercially available, and non-corrosive reagent.
Bismuth(Iii) Bromide In Organic Synthesis. A Catalytic Method For The Allylation Of Tetrahydrofuranyl And Tetrahydropyranyl Ethers, Ram Mohan, Scott Krabbe, Veronica Angeles
Bismuth(Iii) Bromide In Organic Synthesis. A Catalytic Method For The Allylation Of Tetrahydrofuranyl And Tetrahydropyranyl Ethers, Ram Mohan, Scott Krabbe, Veronica Angeles
Scholarship
A bismuth bromide-catalyzed (10.0 mol %) multicomponent reaction involving the allylation of THF- and THP-ethers, followed by in situ derivatization with acetic anhydride to generate highly functionalized esters has been developed under solvent-free conditions. To the best of our knowledge, this is the first report of a catalytic procedure for the allylation of THF- and THP-ethers to yield ring-opened products.