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Full-Text Articles in Chemistry
Stimuli-Responsive Polymersomes And Surface Functionalized Dendrimersomes: Platforms For Biomedical Applications, J Trevor Mcintosh
Stimuli-Responsive Polymersomes And Surface Functionalized Dendrimersomes: Platforms For Biomedical Applications, J Trevor Mcintosh
Electronic Thesis and Dissertation Repository
Amphiphilic block copolymers (BCPs) and dendrimers are known to self-assemble in aqueous solution to form a number of aggregate morphologies. These different architectures are largely a function of the hydrophilic volume or weight fractions of the different components of the polymer system. One possible morphology is a vesicle, also referred to as a polymersome or dendrimersome when BCPs or dendrimers, respectively, are used. Vesicles are multi-functional, supramolecular, bilayer assemblies, whose potential for stimuli-responsiveness and surface functionalization make them promising materials for a variety of biomedical applications. This thesis demonstrates the use of UV-sensitive block copolymers forming photodegradable vesicles, as well …
Development Of Biodegradable And Stimuli-Responsive Macromolescules And Their Assemblies, Ali Nazemi
Development Of Biodegradable And Stimuli-Responsive Macromolescules And Their Assemblies, Ali Nazemi
Electronic Thesis and Dissertation Repository
Polymersomes are potentially multifunctional soft materials constructed by the self-assembly of amphiphilic block copolymers in aqueous medium. While much research has focused on controlling the assembly and encapsulation properties of polymersomes, their surface functionalization has been relatively unexplored. This is important because it plays a critical role in determining their properties such as toxicity and biodistribution behavior. The work described in this thesis involves the development of a biocompatible and biodegradable polymersome systems based on poly(ethylene oxide)-b-polycaprolactone (PEO-PCL) block copolymers with azide surface groups as a novel scaffold for various biomedical applications. The surface functionalization of these polymersomes …