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Capillary Electrophoresis/Tandem Mass Spectrometry With Array Detection, L.J. Deterding, K.B. Tomer, J.M.Y. Wellemans, Ronald Cerny, M.L. Gross

Ronald Cerny Publications

Mixtures of standard compounds of biological interest were analyzed by capillary electrophoresis in conjunction with tandem four sector mass spectrometry (MS/MS) using an array detector. Capillary electrophoresis offers extremely high separation efficiencies while array detection allows for the simultaneous acquisition of a large fraction of a tandem mass spectrum and high utilization of the sample ions produced. Consequently, improvements in sensitivity and structural information were observed for the combined techniques in comparison to similar measurements with a four-sector and a single-point detector. Coaxial continuous-flow fast atom bombardment was used to create (M + H) precursor ions of the separated analyses …