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Mechanisms Of Hemoglobin Adaptation To High Altitude Hypoxia, Jay F. Storz, Hideaki Moriyama
Mechanisms Of Hemoglobin Adaptation To High Altitude Hypoxia, Jay F. Storz, Hideaki Moriyama
Hideaki Moriyama Publications
Evidence from a number of vertebrate taxa suggests that modifications of hemoglobin (Hb) function may often play a key role in mediating an adaptive response to high altitude hypoxia. The respiratory functions of Hb are a product of the protein’s intrinsic O2-binding affinity and its interactions with allosteric effectors such as protons, chloride ions, CO2, and organic phosphates. Here we review several case studies involving high altitude vertebrates where it has been possible to identify specific mechanisms of Hb adaptation to hypoxia. In addition to comparative studies of Hbs from diverse animal species, functional studies of …
Mechanisms Of Hemoglobin Adaptation To High Altitude Hypoxia, Jay F. Storz, Hideaki Moriyama
Mechanisms Of Hemoglobin Adaptation To High Altitude Hypoxia, Jay F. Storz, Hideaki Moriyama
Hideaki Moriyama Publications
Evidence from a number of vertebrate taxa suggests that modifications of hemoglobin (Hb) function may often play a key role in mediating an adaptive response to high altitude hypoxia. The respiratory functions of Hb are a product of the protein’s intrinsic O2-binding affinity and its interactions with allosteric effectors such as protons, chloride ions, CO2, and organic phosphates. Here we review several case studies involving high altitude vertebrates where it has been possible to identify specific mechanisms of Hb adaptation to hypoxia. In addition to comparative studies of Hbs from diverse animal species, functional studies of …