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Supporting Information For "The Molecular Basis Of High-Altitude Adaptation In Deer Mice", Jay F. Storz, Stephen J. Sabatino, Federico G. Hoffmann, Eben J. Gering, Hideaki Moriyama, Nuno Ferrand, Bruno Monteiro, Michael W. Nachman
Supporting Information For "The Molecular Basis Of High-Altitude Adaptation In Deer Mice", Jay F. Storz, Stephen J. Sabatino, Federico G. Hoffmann, Eben J. Gering, Hideaki Moriyama, Nuno Ferrand, Bruno Monteiro, Michael W. Nachman
Hideaki Moriyama Publications
Figure S1: Variation in Site-Specific Levels of Altitudinal Differentiation across the 5′ α- Globin Gene of P. maniculatus
Figure S2: Relationship between Pairwise Linkage Disequilibrium and Distance in bp
Genbank Accession Numbers
Table S1: Amino Acid Variation in the α-Globin Genes of High- and Low-Altitude Deer Mice: Amino acid replacement polymorphisms in deer mice where the derived variant is present at a frequency of >0.100 in the high-altitude sample.
Table S2: Additional Information on Sequenced Loci: Primer sequences for nuclear loci in P. maniculatus.
The Molecular Basis Of High-Altitude Adaptation In Deer Mice, Jay F. Storz, Stephen J. Sabatino, Federico G. Hoffmann, Eben J. Gering, Hideaki Moriyama, Nuno Ferrand, Bruno Monteiro, Michael W. Nachman
The Molecular Basis Of High-Altitude Adaptation In Deer Mice, Jay F. Storz, Stephen J. Sabatino, Federico G. Hoffmann, Eben J. Gering, Hideaki Moriyama, Nuno Ferrand, Bruno Monteiro, Michael W. Nachman
Hideaki Moriyama Publications
Elucidating genetic mechanisms of adaptation is a goal of central importance in evolutionary biology, yet few empirical studies have succeeded in documenting causal links between molecular variation and organismal fitness in natural populations. Here we report a population genetic analysis of a two-locus a-globin polymorphism that underlies physiological adaptation to high-altitude hypoxia in natural populations of deer mice, Peromyscus maniculatus. This system provides a rare opportunity to examine the molecular underpinnings of fitness-related variation in protein function that can be related to a well-defined selection pressure. We surveyed DNA sequence variation in the duplicated α -globin genes of P. maniculatus …
Apparatus And Method For Growing Crystal, And Apparatus And Method For Analyzing Crystal: United States Patent No. 7,156,917 B2, Hideaki Moriyama, Norio Sugi, Kazunori Kawasaki, Shoji Muramatsu
Apparatus And Method For Growing Crystal, And Apparatus And Method For Analyzing Crystal: United States Patent No. 7,156,917 B2, Hideaki Moriyama, Norio Sugi, Kazunori Kawasaki, Shoji Muramatsu
Hideaki Moriyama Publications
An apparatus for growing a biological macromolecular crystal by vaporizing biological macromolecular solution into an oversaturated state. The apparatus includes a first sealed room that receives first crystallizing agent solution, and a communicating tube that communicates with the first sealed room and has a small sectional area for suppressing convection of air. A plurality of droplets of solution dissolving a biological macromolecule and a crystallizing agent therein are held in the communicating tube with the plurality of droplets being separated from each other.