Chemistry Commons^™

The Application Of Stereolithography To The Creation Of Molecular Models Of Amiloride And Its Analogues, Thomas John Busanic

Theses

Stereolithography, a process by which a computer-guided Ultraviolet (UV) laser is applied onto a liquid monomer resin to form a solid polymer, was used to create solid models of amiloride and two of its analogues. The Cartesian coordinates used as input for the orientation of each atom in a molecule were calculated using ab initio molecular orbital theory. Since the structures of the molecules are calculated in this fashion, they represent a more accurate representation of the molecules than that provided by standard molecular modeling kits.

The original purpose of this work was to assist a blind chemist in appreciating …

Oxidation Of Cyclohexene With Aqueous Potassium Peroxymonosulfate At Ph < 1.7, Wen-Qing Sun

Theses

Glycols are often used as starting materials for pharmaceuticals. They are currently manufactured by reacting alkenes with organic peroxy acids in organic solutions that contain chlorinated solvents. The aim of this research is to find ways to avoid the use of hazardous organic solvents in the manufacture of pharmaceuticals in order to prevent pollution. Our approach is to find alternative synthetic methods using water as solvent.

Based on literature information, it was decided to determine if the aqueous potassium peroxymonosulfate oxidation of water-immiscible cyclohexene at room temperature can be scaled up to become a new method to manufacture glycols. Acidic …

Catalytic Oxidation Of Chlorinated Hydrocarbons Over Powdered Transition Metal Oxide, Sanmei Xu

Theses

This study addresses the ability of powdered transition metal oxides such as manganese oxide, iron oxide and copper oxide to catalytically oxidize low concentrations of chlorinated hydrocarbons with air. The catalytic oxidation of trichloroethylene and dichloromethane in a tubular reactor system was evaluated experimentally as a function of temperature and space velocity. Gas chromatography with electron capture detector and flame ionization detector was used for quantitative analysis of feed and product streams. Gas chromatography/mass spectrometry and gas chromatography/Fourier transform infrared spectroscopy were used to identify all oxidation products. The results indicate that over 99% conversion of trichloroethylene is achieved at …