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Full-Text Articles in Chemistry
High Glucose Enhances The Proliferation Effects Of Stress Hormones In Mesenchymal Stem Cell Cultures, Jodi F. Evans Ph.D., Nancy Abrego, Louis Ragolia
High Glucose Enhances The Proliferation Effects Of Stress Hormones In Mesenchymal Stem Cell Cultures, Jodi F. Evans Ph.D., Nancy Abrego, Louis Ragolia
Faculty Works: Biology, Chemistry, and Environmental Studies
Mesenchymal stem cells (MSC) are the progenitor cells to connective tissue cells, epithelial cells, and smooth muscle cells. These cells are currently being investigated as a cellular source for tissue regeneration and repair. The systemic and local tissue environment may have significant influence on the success of such efforts. We hypothesized that elevated glucose and exposure to stress hormones would influence the proliferation of MSC. MSC from the bone marrow of Wistar-Kyoto (WKY) rats were grown under both low glucose (5 mM) and high glucose (20 nM) conditions in the presence and absence of the synthetic glucocorticoid, dexamethasone, and adrenocorticotropin …
Stress Axis Hormones Induce Triglyceride Filled Nodule Formation In Vascular Smooth Muscle Cells, Jodi F. Evans Ph.D., Michelle Vigliotti, Pamela Tello
Stress Axis Hormones Induce Triglyceride Filled Nodule Formation In Vascular Smooth Muscle Cells, Jodi F. Evans Ph.D., Michelle Vigliotti, Pamela Tello
Faculty Works: Biology, Chemistry, and Environmental Studies
Homeostatic stress, such as that which occurs in diabetes, is associated with increased risk for the development of atherosclerosis. Atherosclerotic plaques of the artery wall are associated with both lipid accumulation and fibrous and/or calcified tissue accumulation. Vascular smooth muscle cells (VSMC) are derived from mesenchymal stem cells (MSC) which are capable of differentiating into adipocytes, chondrocytes and osteoblasts. MSC of the bone marrow are pushed toward the chondrogenic and adipogenic phenotypes in the presence of the stress hormones glucocorticoid and adrenocorticotropin (ACTH). This led us to hypothesize that the proliferative VSMC of the Goto-Kakizaki (GK) diabetic rat, when exposed …