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Full-Text Articles in Chemistry
Synthesis And Singlet Oxygen Generation Of Boron- 2-(4,5-Dibromo-1h-Imidazole-2-Yl)-3,5-Dipyrazolopyridine Complex For Antimicrobial Photodynamic Therapy, Zeynep Ekmekçi̇, Seda Karaoğlu
Synthesis And Singlet Oxygen Generation Of Boron- 2-(4,5-Dibromo-1h-Imidazole-2-Yl)-3,5-Dipyrazolopyridine Complex For Antimicrobial Photodynamic Therapy, Zeynep Ekmekçi̇, Seda Karaoğlu
Turkish Journal of Chemistry
In this study, the pyridine side of a boron 2-(2'-pyridyl) imidazole (BOPIM) core, which has very few derivatives synthesized in the literature and can show fluorescence properties in solid form, was derivatized with 1-methylpyrazole, predicted to have activity against fungi or bacteria according to the literature. Additionally, its imidazole side was brominated to increase the efficiency of singlet oxygen production by increasing the intersystem crossing. The photophysical properties of the new synthesized BOPIM derivative were investigated in general organic solvents with different polarities. While the wavelength of the maximum absorbance was determined as 406 nm in CH2Cl2 and THF, the …
Water-Soluble Phthalocyanine Photosensitizers For Photodynamic Therapy, İpek Ömeroğlu, Mahmut Durmuş
Water-Soluble Phthalocyanine Photosensitizers For Photodynamic Therapy, İpek Ömeroğlu, Mahmut Durmuş
Turkish Journal of Chemistry
Photodynamic therapy (PDT) is based on a photochemical reaction that is started when a photosensitizing process is activated by the light and results in the death of tumor cells. Solubility is crucial in PDT applications to investigate the physical and chemical characteristics of phthalocyanines, but, unfortunately, most phthalocyanines show limited solubility especially in water. To increase the solubility of phthalocyanines in polar solvents and water, ionic groups such as -SO3 - , -NR3 +, -COO- , and nonionic groups such as poly-oxy chains are frequently added to the peripheral or nonperipheral positions of the phthalocyanine framework. Since water-solubility and NIR-absorbing …
Comparatively Sonophotochemical And Photochemical Studies Of Phthalocyanines With Cationic Substituents On Nonperipheral Positions, Mukaddes Özçeşmeci̇, Ceren Can Karanlik, Ali̇ Erdoğmuş, Esi̇n Hamuryudan
Comparatively Sonophotochemical And Photochemical Studies Of Phthalocyanines With Cationic Substituents On Nonperipheral Positions, Mukaddes Özçeşmeci̇, Ceren Can Karanlik, Ali̇ Erdoğmuş, Esi̇n Hamuryudan
Turkish Journal of Chemistry
The term sonophotodynamic therapy (SPDT) refers to a combination of sonodynamic therapy (SDT) and photodynamic therapy (PDT), in which the efficacy of the treatment is boosted by utilizing the proper amount of a sensitizer that is responsive to both light and ultrasound. Although it has been proven in photophysicochemical studies that SPDT enhances singlet oxygen production, related studies in the literature are very limited. Considering this situation, this study aims to investigate the efficacy of synthesized phthalocyanines in terms of PDT and SPDT. The singlet oxygen quantum values calculated as 0.13 for 5, 0.44 for 6, and 0.61 for 7 …