Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Chemistry
Synthesis Of Hydroxy Benzoin/Benzil Analogs And Investigation Of Their Antioxidant,Antimicrobial, Enzyme Inhibition, And Cytotoxic Activities, Nuretti̇n Yayli, Gözde Kiliç, Gonca Çeli̇k, Nuran Kahri̇man, Şeyda Kanbolat, Ari̇f Bozdeveci̇, Şengül Alpay Karaoğlu, Rezzan Ali̇yazicioğlu, Hasan Erdi̇nç Selli̇tepe, İnci̇ Seli̇n Doğan, Ali̇ Aydin
Synthesis Of Hydroxy Benzoin/Benzil Analogs And Investigation Of Their Antioxidant,Antimicrobial, Enzyme Inhibition, And Cytotoxic Activities, Nuretti̇n Yayli, Gözde Kiliç, Gonca Çeli̇k, Nuran Kahri̇man, Şeyda Kanbolat, Ari̇f Bozdeveci̇, Şengül Alpay Karaoğlu, Rezzan Ali̇yazicioğlu, Hasan Erdi̇nç Selli̇tepe, İnci̇ Seli̇n Doğan, Ali̇ Aydin
Turkish Journal of Chemistry
In this study, hydroxy benzoin (1-7), benzil (8-14), and benzoin/benzil-O-β-D-glucosides (15-25) were synthesized to investigate their biological activities. An efficient method for synthesizing hydroxy benzoin compounds (1-7) was prepared from four different benzaldehydes using an ultrasonic bath. Then, antioxidant (FRAP, CUPRAC, and DPPH), antimicrobial (3 Gram (-), 4/6 Gram (+), one tuberculosis and one fungus), and enzyme inhibition (acetylcholinesterase, butyrylcholine esterase, tyrosinase, α-amylase, and α- glucosidase) for the all synthesized compounds (1-25) were evaluated. And also, four most active compounds (4, 12, 18a+b, and 25) from each group were evaluated to the human cervical cancer cell line (HeLa) and anticancer …
Cytotoxic And Apoptotic Effects Of Hypericum Androsaemum On Prostate Adenocarcinoma(Pc-3) And Hepatocellular Carcinoma (Hep G2) Cell Lines With Identification Of Secondarymetabolites By Lc-Hrms, Nurdan Yazici Bektaş, Ezgi̇ Ersoy, Mehmet Boğa, Tuğçe Boran, Ercan Çinar, Gül Özhan, Ahmet Ceyhan Gören, Esra Eroğlu Özkan
Cytotoxic And Apoptotic Effects Of Hypericum Androsaemum On Prostate Adenocarcinoma(Pc-3) And Hepatocellular Carcinoma (Hep G2) Cell Lines With Identification Of Secondarymetabolites By Lc-Hrms, Nurdan Yazici Bektaş, Ezgi̇ Ersoy, Mehmet Boğa, Tuğçe Boran, Ercan Çinar, Gül Özhan, Ahmet Ceyhan Gören, Esra Eroğlu Özkan
Turkish Journal of Chemistry
The study aims to determine the secondary metabolites of Hypericum androsaemum L. extracts by liquid chromatographyhigh resolution mass spectrometry (LC-HRMS), and investigate the antioxidant and cytotoxic activities of the plant. Cytotoxic activity was evaluated by MTT assay, and apoptosis induction abilities on human prostate adenocarcinoma (PC-3), and hepatocellular carcinoma (Hep G2) cell lines. Accordingly, major secondary metabolites were found as hederagenin (762 ± 70.10 μg/g) in the leaves dichloromethane (LD), herniarin (167 ± 1.50 μg/g) in fruit dichloromethane (FD), (-)-epicatechin (6538 ± 235.36 μg/g) in the leaves methanol (LM), (-)-epigallocatechin gallate (758 ± 20.46 μg/g) in the fruit methanol (FM), …
Gc-Ms Analyses And Bioactivities Of Essential Oil Obtained From The Roots Ofchrysopogon Zizanioides (L.) Roberty Cultivated In Giresun, Turkey, Derya Efe, Mustafa Karaköse, Ayça Aktaş Karaçeli̇k, Bengü Ertan, Mehmet Emi̇n Şeker
Gc-Ms Analyses And Bioactivities Of Essential Oil Obtained From The Roots Ofchrysopogon Zizanioides (L.) Roberty Cultivated In Giresun, Turkey, Derya Efe, Mustafa Karaköse, Ayça Aktaş Karaçeli̇k, Bengü Ertan, Mehmet Emi̇n Şeker
Turkish Journal of Chemistry
The essential oils (EOs) constituents have trade importance due to their bioactivities. In this research, the essential oil of the roots of Chrysopogon zizanioides (L.) Roberty cultivated in Giresun was obtained by hydrodistillation. Then, the chemical composition and biological activities of Chrysopogon zizanioides root essential oil (CEO) were studied. Thirty compounds were identified by gas chromatography-mass spectrometry (GC-MS) and the major compounds were determined as isobutyl-angelate (11.15%), α-muurolene (10.56%), α-cedrene (8.42%), α-patchoulene (8.10%), and ethylene brassylate (7.49%). The antimicrobial effect of CEO was investigated against pathogenic bacteria and fungus. Minimal inhibition concentration (MIC) was determined 31.25 μg/mL against C. albicans …