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Synthesis And Antinociceptive Activity Of 2-[(2-Oxobenzothiazolin-3-Yl)Methyl]- 5-Aminoalkyl/Aryl-1,3,4-Thiadiazole, Ti̇jen Önkol, Bi̇lge Çakir, M. Fethi̇ Şahi̇n, Engi̇n Yildirim, Kevser Erol
Synthesis And Antinociceptive Activity Of 2-[(2-Oxobenzothiazolin-3-Yl)Methyl]- 5-Aminoalkyl/Aryl-1,3,4-Thiadiazole, Ti̇jen Önkol, Bi̇lge Çakir, M. Fethi̇ Şahi̇n, Engi̇n Yildirim, Kevser Erol
Turkish Journal of Chemistry
Ten 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminoalkyl/aryl-1,3,4-thiadiazole derivatives were synthesized. The chemical structures of these compounds were elucidated by their FT-IR and ^1H-NMR spectral data, as well as their elemental analyses. The compounds were tested for antinociceptive activity. Among these compounds, 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminomethyl-1,3,4-thiadiazole (5a) was found to be significantly more active than the others and the standards in all the tests.
An Atropisomeric Chiral 2,2'-Bipyridyl-3,3'-Dicarboxylic Acid And Corresponding Platinum(Ii) Complex, Abdurrahman Şengül
An Atropisomeric Chiral 2,2'-Bipyridyl-3,3'-Dicarboxylic Acid And Corresponding Platinum(Ii) Complex, Abdurrahman Şengül
Turkish Journal of Chemistry
2,2'-Bipyridyl-3,3'-dicarboxylic acid (H_2BDC) spontaneously resolves on crystallization from water, giving monohydrated crystals of the space group P2_12_12_1. In any individual crystal, all the atropisomeric-skewed molecules are of one hand; however, on dissolution in water, optical activity is lost. Strong hydrogen bonding leads to a helical structure, via O--H ... N links, and 3 further strong bonds between water and carboxylate groups produce a framework structure. The pK_a values measured for H_2BDC (3.18 \pm 0.04 and 4.59 \pm 0.02 at 20 \pm 1 °C, in dilute aqueous solution) agree with the zwitterionic form. The reaction of H_2BDC with potassium tetrachloroplatinate(II) in …