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Full-Text Articles in Chemistry
A Novel, Ultra-Fast Electrochemical Tool To Study Speciation Of Trace Metals In Aqueous Solution, Pavithra Pathirathna
A Novel, Ultra-Fast Electrochemical Tool To Study Speciation Of Trace Metals In Aqueous Solution, Pavithra Pathirathna
Wayne State University Dissertations
Trace metals play important roles in biological and ecological systems. In biology, trace metals act as catalytic or structural cofactors and regulate biochemical processes. In the environment, natural and anthropogenic sources of trace metals mobilized into natural waters where they can create harmful and persistent pollution. Trace metal chemistry in physiological and environmental systems can fluctuate rapidly which makes it difficult to clearly define trace metals’ roles in these systems with traditional analytical methods. Furthermore, these systems are often chemically harsh and physically delicate (e.g. the brain), factors that add to the challenge of analysis in real systems. Fast scan …
Evaluation Of Presynaptic Dopamine Dynamics After: Toluene Inhalation Or Trkb Receptor Activation, Aaron Kwaku Apawu
Evaluation Of Presynaptic Dopamine Dynamics After: Toluene Inhalation Or Trkb Receptor Activation, Aaron Kwaku Apawu
Wayne State University Dissertations
Dopamine (DA) neurons in the striatum mediate several functions of the brain and have been linked to a host of neurological disorders including Parkinson's disease and addiction, both of which occur as a result of dysfunction in the DA system. In the present study, our first objective was to understand how the striatal DA system adapts to acute and repeated administration of inhalant toluene. The use of toluene as inhalant, like other drugs of abuse, is known to perturb DA neurotransmission in the brain reward pathway. However, the exact mechanism underling toluene's influence on striatal DA neurotransmission is unknown. The …
Striatal Dopamine Dynamics Upon Manganese Accumulation, Madiha Khalid
Striatal Dopamine Dynamics Upon Manganese Accumulation, Madiha Khalid
Wayne State University Dissertations
STRIATAL DOPAMINE DYNAMICS UPON MANGANESE ACCUMULATION
by MADIHA KHALID
August 2013
Advisor: Dr. Tiffany Mathews
Major: Chemistry (Analytical)
Degree: Doctor of Philosophy
Although manganese (Mn) is fundamental for many biological processes, exposure to excess amounts leads to a neurological disorder termed manganism. Due to its symptomatic similarity to Parkinson's disease, as well its preferential accumulation in dopamine rich brain regions, alterations in the dopamine system are implicated in the onset of manganism. In my research, Mn overexposure is mimicked via subcutaneous administration of manganese chloride to C57BL/6 mice over the course of seven days using a protocol that has been …