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Interactions Of Cis-Bis Ruthenium Complexes With Monosaccharides, Lindsay Mcdonald
Interactions Of Cis-Bis Ruthenium Complexes With Monosaccharides, Lindsay Mcdonald
Undergraduate Review
Molecular recognition and binding of oligosaccharides play an essential role in many biological processes including cell-cell recognition, signaling and adhesion. Our group is currently involved in the development of metal based receptors that can effectively bind specific glycoconjugates. Species that can selectively bind and chemically alter membrane glycoconjugates have the potential to inhibit tumor cell metastasis, inflammation and fibrosis. As an initial step towards our goal the interactions of cis-Ru(bpy)2(DMF)22+ (bpy = bipyridine, DMF = dimethylformamide) and cis-Ru(acac)2(CH3CN)2+ (acac = acetylacetonate) with the monosaccharides glucose and mannose have been examined …