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Synthesis Of Some New 1-Acylthiosemicarbazides And 1,2,4-Triazol-5-Thiones, And Their Analgesic And Anti-Inflammatory Activities, Yasemi̇n Dündar, Bi̇lge Çakir, Esra Küpeli̇, M. Fethi̇ Şahi̇n, Ni̇ngur Noyanalpan
Synthesis Of Some New 1-Acylthiosemicarbazides And 1,2,4-Triazol-5-Thiones, And Their Analgesic And Anti-Inflammatory Activities, Yasemi̇n Dündar, Bi̇lge Çakir, Esra Küpeli̇, M. Fethi̇ Şahi̇n, Ni̇ngur Noyanalpan
Turkish Journal of Chemistry
We synthesized new 1-[3-(2-oxobenzothiazolin-3-yl)propanoyl]-4- substituted-thiosemicarbazides and their corresponding cyclized 3-[2-(2-oxobenzothiazoline-3-yl)ethyl]-4-substituted-1,2,4-triazol-5-thione ana-logs in which position 4 of the triazole ring was substituted by cyclohexyl, methyl, allyl, phenyl, p-methylphenyl, p-methoxyphenyl, p-chlorophenyl, p-nitrophenyl, benzyl, and phenylethyl to screen their analgesic and anti-inflammatory activities as well as gastric ulceration potential in test animals. None of the compounds, except 5a, 5e, and 5h, caused gastric lesions or bleeding. Compound 5g was found to have higher analgesic and anti-inflammatory activity among the synthesized compounds.
Synthesis Of Some New Pyridylethylated Benzoxa(Thia)Zolinones With Analgesic Activitiy, Nesri̇n Gökhan, Göknur Aktay, Hakki Erdoğan
Synthesis Of Some New Pyridylethylated Benzoxa(Thia)Zolinones With Analgesic Activitiy, Nesri̇n Gökhan, Göknur Aktay, Hakki Erdoğan
Turkish Journal of Chemistry
Eighteen new 3-[2-(2-/4-pyridyl)ethyl]benzoxazolinone (benzothiazolinone) derivatives were synthesized by reacting 2-/4-vinylpyridine and appropriate benzoxazolinones and benzothiazolinones. The analgesic activities of these compounds were investigated by modified Koster and hot-plate tests. Test results revealed that most of the compounds at 100 mg/kg dose levels have higher analgesic activities than acetylsalicylic acid. Compounds with bromo substituents on the phenyl ring in the 6-position of the main ring seemed to show less activity than those with fluorinated ones. Compound 6b showed remarkably high activity in the hot-plate test, although it was inactive in the Koster test. However compound 3a had statistically significant high peripheral …