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Methods Development In Biological Mass Spectrometry: Application In Glycoproteomics, Sanja Trajkovic
Methods Development In Biological Mass Spectrometry: Application In Glycoproteomics, Sanja Trajkovic
Theses and Dissertations--Chemistry
Proteomics refers to global characterization of the full set of proteins present in a biological sample. Various analytical disciplines contribute to proteomics but mass spectrometry became method of choice for analysis of complex protein samples.
Mass spectrometry allows for high throughput analysis of the proteome but, moreover, it has the ability to acquire higher-order information such as post-translational modifications (PTM). Glycosylation is the most abundant PTM on eukaryotic proteins.
This dissertation will focus on method development for structural proteomics that will be utilized to explain the glycoproteome of obligate intracellular protozoan parasite Toxoplasma gondii as a model system.
Optimization of …