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Inducible Dna Interstrand Cross-Linking Agents: Design, Synthesis, Mechanism, And Biomedical Applications, Muhammad Asad Uz Zaman
Inducible Dna Interstrand Cross-Linking Agents: Design, Synthesis, Mechanism, And Biomedical Applications, Muhammad Asad Uz Zaman
Theses and Dissertations
DNA is the carrier of genetic information, making its chemical reactivity and function extremelyimportant. DNA interstrand cross-links (ICL) leads to covalent bind of two strands, which prevents the separation of double helix. DNA ICLs are the sources of the cytotoxicity of antitumor and anticancer agents. This thesis focuses on investigating the reactivity of a varieties of aromatic compounds towards DNA. Some of these molecules can be activated by photo irradiation to induce DNA ICL formation via alkylation. Others undergo activation by H2O2 to release DNA cross-linking agents. We investigated the mechanism of function of these inducible DNA cross-linking agents as …