Chemistry Commons^™

A Mild One-Pot Conversion Of Alkenes Into Amines Through Tandem Ozonolysis And Reductive Amination, Shivakumar Kyasa, Thomas J. Fisher, Patrick Dussault

Patrick Dussault Publications

The selective reduction of hydroperoxyacetals to aldehydes by sodium triacetoxyborohydride provides the basis for a mild one-pot synthesis of amines from alkenes.

Includes Supplementary Materials.

Phytosterol Stearate Esters Elicit Similar Responses On Plasma Lipids And Cholesterol Absorption But Different Responses On Fecal Neutral Sterol Excretion And Hepatic Free Cholesterol In Male Syrian Hamsters, Mark M. Ash, Jiliang Hang, Patrick Dussault, Timothy P. Carr

Patrick Dussault Publications

The dietary impact of specific phytosterols incorporated into phytosterol fatty acid esters has not been elucidated. Therefore, we tested the hypothesis that phytosterol esters containing different sterol moieties (sitosterol, sitostanol, or stigmasterol) but the same fatty acid moiety (stearic acid) produce different effects on cholesterol metabolism. Male Syrian hamsters were fed sitosterol, sitostanol, and stigmasterol stearate esters (25 g/kg diet) in an atherogenic diet containing cholesterol (1.2 g/kg) and coconut oil (80 g/kg). The phytosterol stearates produced no decrease in cholesterol absorption or plasma non–high-density lipoprotein cholesterol despite a reduction in liver free cholesterol in hamsters fed both sitosterol and …

N5-Phosphonoacetyl-L-Ornithine (Palo): A Convenient Synthesis And Investigation Of Influence On Regulation Of Amino Acid Biosynthetic Genes In Saccharomyces Cerevisiae, Brad Johnson, Rachel Steadman, Krista D. Patefield, Jeffrey J. Bunker, Audrey L. Atkin, Patrick Dussault

Patrick Dussault Publications

A scalable four-step synthesis of the ornithine transcarbamylase inhibitor N⁵-phosphonoacetyl-L-ornithine (PALO) is achieved through boroxazolidinone protection of ornithine. Investigations in the model organism Saccharomyces cerevisiae found that, in contrast to a previous report, PALO did not influence growth rate or expression of genes involved in arginine metabolism.

Reversible Collapse Of The Langmuir Films Of A Series Of Triphenylsilyl Ether-Terminated Amphiphiles, Christine A. Devries, James J. Haycraft, Qiang Han, Farhana Noor-E-Ain, Joseph Raible, Patrick Dussault, Craig J. Eckhardt

Patrick Dussault Publications

The Langmuir films of a series of triphenylsilyl ether (TPSE)-terminated amphiphiles were investigated in order to explore the bulge amphiphile model developed by Haycraft et al. [Thin Solid Films, 515 (2007) 2990]. The TPSE series was examined using surface pressure– surface area isotherms over a range of temperatures (287–298 K) with simultaneous acquisition of Brewster angle microscopy images. The Langmuir films of the TPSE series exhibit the reversible collapse process characteristic of bulge amphiphiles, including an observation consistent with the reversed cybotactic cluster model and increased entropy upon collapse. No solid-like monolayer phases were found over the temperature …