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Full-Text Articles in Chemistry
Synthesis And Performance Of Novel Supramolecular Tools For Single-Particle Cryogenic Electron Microscopy And Drug And Gene Delivery, Kyle J. Wright
Synthesis And Performance Of Novel Supramolecular Tools For Single-Particle Cryogenic Electron Microscopy And Drug And Gene Delivery, Kyle J. Wright
Open Access Dissertations
High-resolution biomacromolecular structure elucidation is fundamentally important to structure-based drug design and basic research into complex biochemical processes. Cryo-EM is an emerging alternative to XRD and NMR that is complementary in many ways relative to XRD and NMR. Materials approaches to cryo-EM are anticipated to greatly facilitate the cryo-EM process, allowing progress toward a more high-throughput application of cryo-EM to address challenges in structural biology. ^ Various affinity-based approaches inspired by approaches previously introduced for 2D crystallization were developed for facilitation of cryo-EM. A library of affinity lipopolymer constructs were synthesized consisting of lipopolymers of various PEG molecular weights conjugated …
Kinetics And Mechanisms Of Amine Bis-Phenolate Polymerization Catalysts Featuring Titanium, Zirconium, Or Hafnium Centers, Paul Daniel Pletcher
Kinetics And Mechanisms Of Amine Bis-Phenolate Polymerization Catalysts Featuring Titanium, Zirconium, Or Hafnium Centers, Paul Daniel Pletcher
Open Access Dissertations
The story of Group IV metallocene polymerization catalysts has been a tremendous success in the ability to tune chemical reactivity through structural design. As new, nonmetallocene catalyst systems are being investigated, there has been a lack of quantitative relationships for predicting optimal catalyst design for both desired reactivity and polymeric properties. By utilizing a rational catalyst design strategy that focuses on obtaining a quantitative kinetic analysis of all relevant chemical steps from a family of related catalysts, we have attempted to correlate the fundamental reactivity within the olefin polymerization mechanism to distinctive chemical structures. Such studies have revealed both predictive, …