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Lanthanide Complexes As Fluorescent Indicators For Neutral Sugars And Cancer Biomarkers, Onur Alpturk
Lanthanide Complexes As Fluorescent Indicators For Neutral Sugars And Cancer Biomarkers, Onur Alpturk
LSU Doctoral Dissertations
Simple water soluble lanthanum and europium complexes are effective at detecting neutral sugars as well as glyco- and phospholipids. In solutions at physiologically relevant pH the fluorescent lanthanum complex binds neutral sugars with apparent binding constants comparable to those of arylboronic acids. Interference from commonly occurring anions is minimal. The europium complex detects sialic acid-containing gangliosides at pH 7.0 over an asialoganglioside. This selectivity is attributed, in large part, to the cooperative complexation of the oligosaccharide and sialic acid residues to the metal center, based on analogous prior studies. In MeOH, lysophosphatidic acid (LPA), a biomarker for several pathological conditions …