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Multifunctional Organoboron Compounds And Boralactonate Salts, Randika T. Abeysinghe

Graduate Theses, Dissertations, and Problem Reports

Organoboron compounds have gathered an important significance within the chemistry community on account of their wide range of applications in synthesis, catalysis, and medicinal chemistry. Even though the uses of boron compounds in drug discovery have been overlooked until the last several decades, boronic acid containing molecules have garnered increased attention due to the unique chemical properties of the boron center. Boron-functionalized ��-aryl propionic acid non-steroidal anti-inflammatory drug derivatives (bora-NSAIDs) can be accessed via copper(I)-catalyzed alkene boracarboxylation, using CO2 and B2pin2. To explore and expand the current synthetic and future medicinal chemistry applications of these bora-NSAIDs, methods …