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Electronic Thesis and Dissertation Repository

2016

Bioorthogonal Chemistry

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Click And Bioorthogonal Chemistry For The Chemical Modification Of Nanomaterials, Pierangelo Gobbo Mar 2016

Click And Bioorthogonal Chemistry For The Chemical Modification Of Nanomaterials, Pierangelo Gobbo

Electronic Thesis and Dissertation Repository

The goal of this Ph.D. thesis work is the development of novel reactive nanomaterial templates that can be chemically modified in a facile and robust (i.e., formation of covalent bonds) way for the further modification of the nanomaterial’s physical-chemical properties by the reaction partner molecular system. This type of technology was employed to further expand the application of nanomaterials in nanomedicine, chemical biology and materials science.

In order to reach this goal, as a proof of concept, small (d = 3nm) gold nanoparticles (AuNPs) and carbon nanotubes (CNT) were used as the nanomaterial substrates. Innovative synthetic strategies …