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Articles 1 - 30 of 83
Full-Text Articles in Chemistry
Impact Of Solar Radiation On Perchlorate Formation In The Atmosphere: Evidence From Ice Core Measurements, Bishnu Kunwar
Impact Of Solar Radiation On Perchlorate Formation In The Atmosphere: Evidence From Ice Core Measurements, Bishnu Kunwar
Electronic Theses and Dissertations
Perchlorate, which derives from both anthropogenic and natural sources in the current environment, poses a substantial health hazard to humans as it competes with iodine uptake in the thyroid gland. Consequently, there has been considerable concern about minimizing human exposure to environmental perchlorate by restricting its release from man-made sources. However, the absence of a clear understanding regarding the respective contributions of man-made and natural sources has hindered widespread regulation efforts. A 300-year (1700–2007) Summit, Greenland ice core record from a previous study showed relatively stable perchlorate concentrations in Greenland snow prior to 1980, with some elevated perchlorate levels associated …
Advanced Analytical Techniques For The Analysis Of Toxic Inhaled Agent Exposure And Pharmacokinetic Investigation, Sharmin Sultana
Advanced Analytical Techniques For The Analysis Of Toxic Inhaled Agent Exposure And Pharmacokinetic Investigation, Sharmin Sultana
Electronic Theses and Dissertations
Toxic inhalation agents (TIAs) (i.e., chlorine (Cl2), cyanide (HCN), etc.) are highly poisonous. However, they have a variety of industrial uses, such as health, agro-food, building, textiles, transport, leisure activities, cosmetics, etc. In addition, TIAs can be used as chemical agents in terrorist events or conventional warfare. The ability to detect TIAs in biological and environmental samples is important for preparing use, determining individual exposure, limiting hazardous exposure, etc. Therefore, developing simple and sensitive analytical methods for TIAs, TIA metabolites, and antidotes for those toxic agents is very important. The focus of this study was chlorine and cyanide. Chlorine is …
Understanding The Role Of Hba/Hbd Variations On Deep Eutectic Solvent Properties And Activity Using Acetylsalicylic Acid As A Model Drug, Michael Frimpong
Understanding The Role Of Hba/Hbd Variations On Deep Eutectic Solvent Properties And Activity Using Acetylsalicylic Acid As A Model Drug, Michael Frimpong
Electronic Theses and Dissertations
Deep eutectic solvents (DES) are emerging as a versatile class of solvents, attracting considerable attention for their unique solvent properties and potential applications. This study examines the effects of variations in combinations as well as molar ratios of hydrogen-bond acceptor (HBA) and hydrogen-bond donor (HBD) on the structure of DES. It further explores the structure-activity relationship, measured using the rate of acetylsalicylic acid (ASA) degradation in the solvent. The project is based on the model that variations in HBA/HBD combinations and their relative molar ratios impact the solvent structure (hydrogen bonding), observable in physicochemical measurements, infrared (IR), and nuclear magnetic …
Comprehensive Analysis And Forensic Investigation Of Cyanide, Thiocyanate, And 2-Amino-2-Thiazoline-4-Carboxylic Acid In-Ante- And Postmortem Blood Utilizing Advanced Analytical Techniques, Abdullah Hamad Alluhayb
Comprehensive Analysis And Forensic Investigation Of Cyanide, Thiocyanate, And 2-Amino-2-Thiazoline-4-Carboxylic Acid In-Ante- And Postmortem Blood Utilizing Advanced Analytical Techniques, Abdullah Hamad Alluhayb
Electronic Theses and Dissertations
Cyanide (CN), present as cyanide anion (CN-) or hydrogen cyanide (HCN), is a deadly poison. The main mechanism of CN toxicity is blocking terminal electron transfer, leading to cellular hypoxia, cytotoxic anoxia, and potential death. Determining blood CN concen-trations along with its major metabolite, thiocyanate (SCN-), is crucial. A sensitive method for concurrent detection of CN and SCN- from human ante- and post-mortem blood via liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) analysis was devel-oped. The method involved active microdiffusion with chemical modification using naph-thalene-2,3-dicarboxaldehyde (NDA) and taurine, while monobromobimane (MBB) mod-ification was used for SCN-. The method showed good sensitivity for …
Modulatory Effects Of Deacetylated Sialic Acids (A Sugar Residue) In Nk-Mediated Cytotoxicity And Targeted Therapy By Receptor Tyrosine Kinase Inhibitors, Mathias Tawiah Anim
Modulatory Effects Of Deacetylated Sialic Acids (A Sugar Residue) In Nk-Mediated Cytotoxicity And Targeted Therapy By Receptor Tyrosine Kinase Inhibitors, Mathias Tawiah Anim
Electronic Theses and Dissertations
The complex nature of the biology of cancer is still an unraveling science, yielding several biomarkers that have served as molecular targets for detection and treatment of the disease. How sugars, glycans, play a role has remained relatively uninvestigated. Sialic acid (Sia), a sugar residue on the surface of cells, has been identified as a hallmark of cancer and its progression. Sialic acid can be highly functionalized, but we became interested in acetylated Sias. This functional group is modulated by Sialate O- acetylesterase (encoded by the gene SIAE) and Sialate O-acetyltransferase (encoded by CASD1), enzymes that play a crucial role …
Development And Assessment Of Gamified Process-Oriented Guided Inquiry Learning Activities In Undergraduate Large Lecture Chemistry Courses, Nathan Turner
Electronic Theses and Dissertations
No abstract provided.
Design, Synthesis, And Biological Evaluation Of Novel Steroidal Analogs: Potential Anticancer Agents, Trevor Ostlund
Design, Synthesis, And Biological Evaluation Of Novel Steroidal Analogs: Potential Anticancer Agents, Trevor Ostlund
Electronic Theses and Dissertations
Cancer is a malicious disease with low survivability rates primarily due to lack of reliable treatment options. Treatments are often non-specific for patients, and cancer resistance to treatment is becoming more prevalent as fast as new therapies are created. Previous studies in our laboratory have focused on the Epidermal Growth Factor Receptor (EGFR) and its downstream kinase family members as a key target for cancer. This cascade controls cell proliferation, anti-apoptotic effects, cell regulation, and other survival factors. Additionally, ABC transporters, responsible for efflux of chemotherapeutic material from cells, are key targets to combat drug resistance. We first evaluated a …
Development Of Novel Cellular Assay Model And Therapeutic Deep Eutectic Solvents To Optimize The Activity Of Anticancer Agents, Nizam Uddin
Electronic Theses and Dissertations
Multidrug resistance (MDR) is the major burden behind chemotherapeutic treatment failure. It is the principal mechanism by which cancer cells evade chemotherapeutic treatment. As a result, aggressive cancer cells survive and continue uncontrolled cell division. Multidrug resistance affects survival rate of almost all types of cancer patients and death toll rises at an alarming rate. There are seven different mechanisms for evolving MDR. The most common mechanism in efflux activity of overexpressed ABC transporters. MRP1 is a prominent ABC transporter that pumps out a wide variety of anticancer drugs from the cells and thereby reduces intracellular drug concentrations and develops …
Cytotoxicity Profiling And Apoptotic Potential Of Carboxylic Acids-Based Deep Eutectic Solvents On Mammalian Cell Lines, Mavis Korankye
Cytotoxicity Profiling And Apoptotic Potential Of Carboxylic Acids-Based Deep Eutectic Solvents On Mammalian Cell Lines, Mavis Korankye
Electronic Theses and Dissertations
In the past few years, there has been a notable surge in demand for high-purity medicines due to the prevalence of chronic diseases such as cancer, hypertension, diabetes, cardiovascular diseases, and neurological disorders. Considerable efforts have been dedicated to discovering new solvents that are environmentally friendly and cost-effective that are well-suited for industrial applications. Deep eutectic solvents have gained recognition as a highly promising alternative to organic solvents and ionic liquids due to their easily sourced raw materials, simple and cheap preparation methods, high tunability, low volatility, low toxicity, and biodegradability. The industrial utilization of deep eutectic solvents (DESs) is …
Formulation, Structure, And Applications Of Therapeutic, Amino Acid, And Water-Based Deep Eutectic Solvents, Md Sajjadur Rahman
Formulation, Structure, And Applications Of Therapeutic, Amino Acid, And Water-Based Deep Eutectic Solvents, Md Sajjadur Rahman
Electronic Theses and Dissertations
In the design of greener chemicals, deep eutectic solvents (DESs) are considered as one of the most versatile alternative solvents with widespread applications. DESs have the advantages of being nonflammable with negligible vapor pressure compared to traditional solvents. They share many characteristics of ionic liquids, but DESs are cheaper to formulate, typically nontoxic, recyclable, biodegradable, and are suitable for use with biological systems. In my Ph.D. research, three types of emerging and unconventional types of DESs, namely therapeutic DES (THEDES), amino acid-based DES (AADES), and water-based DES (WDES), have been investigated. To formulate these DES easily available and cheaper chemicals, …
The Significance Of A New 11,000-Year Volcanic Record From The South Pole And Inferences From Comparisons With Other Volcanic Records, Derek Lee Brandis
The Significance Of A New 11,000-Year Volcanic Record From The South Pole And Inferences From Comparisons With Other Volcanic Records, Derek Lee Brandis
Electronic Theses and Dissertations
Snow accumulation at the polar regions of the planet preserves chemical substances from the atmosphere creating natural archives. Records of the atmospheric environment including atmospheric chemical composition and the climate can be reconstructed from ice cores from the polar ice sheets. Sulfur emitted by explosive volcanic eruptions is preserved as sulfate in polar snow and can be used to reconstruct the record of volcanic eruptions. Since large volcanic eruptions impact the environment and climate, records of volcanic eruptions from ice cores can help us to study and understand climate change and model the future climate environment. A 1750-m ice core …
Diversity And Inclusion In Science Teaching Learning (Distl): Focusing On The Perspectives Of Undergraduate Students And Graduate Teaching Assistants In The Chemistry Classroom, Albert Aidoo
Electronic Theses and Dissertations
Students in Science, Technology, Engineering and Mathematics (STEM) come with a wide range of experiences and educational backgrounds. There is high attrition rate and low academic achievement among students in STEM areas, specifically in college chemistry courses that are prerequisites for many STEM majors. Hence it is important to look at diversity and inclusion specifically in first- and second-year college chemistry courses to address the challenge of student attrition in STEM. Diversity can be understood as the differences each student brings along the dimensions of prior knowledge, skills, race, ethnicity, sexual orientation, gender, socio-economic status, age, ability, religious or political …
Students’ Perceptions Of Specific Laboratory Curricula On The Learning Experience In Chemistry Courses, Arwa Ali Alshehri
Students’ Perceptions Of Specific Laboratory Curricula On The Learning Experience In Chemistry Courses, Arwa Ali Alshehri
Electronic Theses and Dissertations
Laboratory courses play a key role in developing critical thinking and problem-solving skills and providing experience in certain aspects of a laboratory setting including reactions, materials, and equipment. Prior studies suggest that a laboratory course assists students toward cognitive gain on lecture content. In contrast, other studies conclude that laboratory is uncorrelated with cognitive gain on lecture content. Thus, a discord exists between researchers regarding the role that laboratory experiences play in furthering the understanding of chemistry concepts taught in lectures. The purpose of this research is to examine the impact of two different laboratory curricula on students’ performance in …
Development Of A Chromatographic Method To Authenticate Aspirin Brands, Megan Guetzloff
Development Of A Chromatographic Method To Authenticate Aspirin Brands, Megan Guetzloff
Electronic Theses and Dissertations
Counterfeit pharmaceuticals pose a threat to society that can include inaccurate amounts of the active pharmaceutical ingredient (API), no API, or containing off-target compounds. For example, there are many recent examples of counterfeit pharmaceuticals containing potentially lethal doses (> 2 mg) of fentanyl (i.e., a synthetic opioid). Current measures to combat illicit pharmaceuticals (e.g., unique packaging and product serialization) have merit, however with evolved technologies, counterfeiters can relatively easily simulate these measures and continue to distribute illicit pharmaceuticals. The only accurate way to definitively determine that a suspected counterfeit is, in fact, counterfeit is advanced chemical analysis. However, current methods …
Analysis Of Metabolites And Therapeutics For Toxic Inhaled Agent Exposure, Abigail Bemah Donkor
Analysis Of Metabolites And Therapeutics For Toxic Inhaled Agent Exposure, Abigail Bemah Donkor
Electronic Theses and Dissertations
The inhalation of toxic inhaled agents (TIAs) such as methyl isocyanate and cyanide can compromise an individual’s general health due to their extremely toxic nature. Nonetheless, these gases are used extensively in the electronics, chemical, welding, electroplating industries, etc., increasing the risk of exposure to both civilians and industrial workers. It is therefore very crucial to develop analytical methods for TIA metabolites and therapeutic agents. Methyl isocyanate (MIC), an intermediate in the synthesis of carbamate pesticides is a toxic industrial chemical that causes irritation and damage to the eyes, respiratory tracts, and skin. Due to its reactivity with proteins, protein …
Advanced Analytical Techniques For The Analysis Of Therapeutics Of Toxic Inhalation Agents And Pharmacokinetic Investigation, Subrata Bhadra
Advanced Analytical Techniques For The Analysis Of Therapeutics Of Toxic Inhalation Agents And Pharmacokinetic Investigation, Subrata Bhadra
Electronic Theses and Dissertations
Toxic inhalation agents (TIAs), (i.e., cyanide (CN) and reduced sulfur compounds (RSCs)), including hydrogen sulfide (H2S) and methanethiol (MT)) are extremely poisonous upon exposure. Many TIAs act by inhibiting mitochondrial cytochrome c oxidase, resulting in cellular hypoxia, cytotoxic anoxia, apnea, respiratory failure, cardiovascular collapse, seizure and potentially death. CN is generated in structural fires and cigarette smoke as well as in mining, electroplating and polymer processing, whereas H2S and MT are found in petroleum, oil and natural gas, waste treatment facilities and decaying organic matter. All are common occupational gas exposure hazards in chemical industries and for first responders, including …
Novel Acetylcholine Chloride Based Water Immiscible Deep Eutectic Solvent: Formulation, Characterization And Application In Drug Solubilization, Shiksha Subedi
Novel Acetylcholine Chloride Based Water Immiscible Deep Eutectic Solvent: Formulation, Characterization And Application In Drug Solubilization, Shiksha Subedi
Electronic Theses and Dissertations
Deep eutectic solvents (DESs) are the emerging class of new and inexpensive solvents composed of two or three safe components capable of self-association through hydrogen bond interaction. The depression in the melting point characterizes DESs compared to those of the individual components. These solvents have properties like the traditionally used ionic liquids (ILs), but they can offset the significant drawbacks of ILs, such as biodegradability, toxicity, and complex synthesis. Due to these remarkable advantages, the research in DESs is increasing exponentially. However, current deep eutectic solvents still have limitations to apply to the real chemical industries due to hydrophilicity and …
Therapeutic Immunoglobulin G Surface Mobility Promotes Antibody-Dependent Cellular Phagocytosis By Arp2/3 And Syk Mediated Rearrangement Of Fcγ Receptors, Seongwan Jo
Electronic Theses and Dissertations
Therapeutic antibodies are rapidly growing class of drugs for treating cancers and immunological disorders by targeting specific antigens or blocking certain pathway to inhibit the tumor growth. In cancer immunotherapy, it was found that Fcγ receptor (FcγR) in immune cells play an important role in antibody dependent cell toxicity against tumor cells. Therefore, understanding FcγR activation mechanism, which requires ligation with immunoglobulin (IgG), is crucial to enhance potency of therapeutic antibodies. One crucial immune responses triggered upon FcγR ligation with IgG is phagocytosis which indicates clearing targets by engulfment. It is known that FcγRs form microclusters which gets rearranged during …
Analysis Of Volatile Organic Compounds: Petroleum Emissions And Microbial Degradation, A K M Ahsan Ahmed
Analysis Of Volatile Organic Compounds: Petroleum Emissions And Microbial Degradation, A K M Ahsan Ahmed
Electronic Theses and Dissertations
Volatile organic compounds (VOCs) are abundant in nature and can occur in various forms in a wide variety of sources. Petroleum is one of the major sources of VOCs. Petroleum being the most widely used energy resources of the world, often released to the environment due to emission and leakage or accidental spillage during exploration, transportation and manufacturing. Once released to the environment, petroleum poses a serious threat to the environment due to some of its toxic organic components. Therefore, the analysis of petroleum is critical to understand its effect on the environment and remediation. This dissertation is focused on …
College Students Conceptions Of Particulate Nature Of Matter And The Impact On Research Instrumentation, Bridget Klutse
College Students Conceptions Of Particulate Nature Of Matter And The Impact On Research Instrumentation, Bridget Klutse
Electronic Theses and Dissertations
The main objective of this research was to explore the understanding and conceptions of Particulate Nature of Matter (PNM) with Chem 115 L students as the participants. Conceptions were defined specifically as beliefs and alternative beliefs about topics. The research also assessed the impact of analytical instrumentation in the chemistry laboratory on learning chemistry concepts. Eight questions (8) with multiple choice answers were administered to 10 students at the beginning and after the Fall 2018 semester via selective/purposeful sampling. Data were collected using surveys (pre- and post-surveys) and interviews (pre- and postinterviews), then analyzed quantitatively and qualitatively. The eight questions …
Assaying Bacillus Amyloliquefaciens Isolates 1ba And 1d3 For Biosurfactant Production And Utilization Of Petroleum Hydrocarbons And Phenolic Acids, Pavan Kulkarni
Electronic Theses and Dissertations
Several Bacillus amyloliquefaciens isolates obtained from wheat residue have been studied as biological agents to control wheat diseases. Notable traits of isolates 1BA and 1D3 include growth with high salt (10% NaCl), at temperatures up to 50°C and over a wide pH range. BIOLOG Gen III plates were used to study and further characterize Bacillus amyloliquefaciens 1BA and 1D3. Both isolates showed tolerance to high salt concentration supporting previous studies. They also grew in the presence of lithium chloride, potassium tellurite, and sodium bromate. Both isolates grew at pH 5, with almost identical carbon source utilization fingerprints. However, D-serine, quinic …
Volcanic Impact On Stratospheric Chlorine Chemistry And Perchlorate Formation: Evidence From Ice Cores, Joshua Andrew Kennedy
Volcanic Impact On Stratospheric Chlorine Chemistry And Perchlorate Formation: Evidence From Ice Cores, Joshua Andrew Kennedy
Electronic Theses and Dissertations
Perchlorate, suspected to be chemically formed in both the troposphere and stratosphere, has been recently measured in Arctic snow and ice cores. These comprise both discontinuous snow and ice cores from the Canadian Arctic and a continuous record of perchlorate was compiled from an analysis of Greenland ice cores. While the background perchlorate concentration typically is very low, a few spikes in concentration coinciding with deposition of volcanic sulfate were observed in the Greenland record, suggesting that perchlorate levels in the atmosphere may be impacted by volcanic eruptions. As of yet, no work has been done to investigate the connection …
Development And Validation Of Advanced Analytical Methods For Pesticides, Per- And Polyfluoroalkyl Substances, And Opioids In Soil And Drinking Water, Christopher Skaggs
Development And Validation Of Advanced Analytical Methods For Pesticides, Per- And Polyfluoroalkyl Substances, And Opioids In Soil And Drinking Water, Christopher Skaggs
Electronic Theses and Dissertations
Environmental pollution from contaminants is a serious concern in a world where more and more pesticides and pharmaceuticals are being used, sometimes improperly and in excess. Since pesticides are used on practically every crop on Earth, it’s no surprise that these compounds are detected in soil, water, and processed agricultural commodities meant for human consumption. Additionally, because of the ubiquity of pharmaceuticals, specifically opioids, and their inherent addictive properties, these compounds are being over-consumed. Because current waste-water treatments can be insufficient to remove them from water sources, this consumption has led to the detection of these compounds in drinking water. …
Screening Of Catalysts For The Subcritical Water Depolymerization Of Lignin, Balawanthrao Jadhav
Screening Of Catalysts For The Subcritical Water Depolymerization Of Lignin, Balawanthrao Jadhav
Electronic Theses and Dissertations
The current world population is completely rely on the non-renewable resources such as coal, fossils, and natural gas to get the energy, fuel and value-added chemicals. The increasing the demand of utilizing non renewable resources leads to severe problems such as global warming, climate changes, and environmental pollution. The renewable resources such as wind, solar energy, and biomass is an alternative sources to overcome these problems and to save the environment. Biomass made up with the cellulose, hemicellulose, and Lignin. Lignin is a copolymer of phenolic monomers and inexpensive naturally occurring complex material to produce the value-added chemicals and various …
Technology-Based Culturally Relevant Chemistry Education (Crce), Mercy Adoma Fosu
Technology-Based Culturally Relevant Chemistry Education (Crce), Mercy Adoma Fosu
Electronic Theses and Dissertations
The relevance of chemistry concepts and principles remains a challenge for most students enrolled in college chemistry courses. Part of this problem is the disconnect with what students experience in their every-day lives, and how the material, specifically chemistry content is presented via textbooks, lectures, and laboratory teaching. Moreover, the teaching of general chemistry has traditionally focused on traditional, instructor-centric expository delivery of course materials, that treats students as empty vessels devoid of prior knowledge. Students prior knowledge and experiences are crucial in shaping their understanding of scientific concepts and principles. Even students with relatively low expectations for success in …
Implementing And Assessing The Use Of A New Strategy For Training Chemistry Graduate Teaching Assistants, Amanda Hyett
Implementing And Assessing The Use Of A New Strategy For Training Chemistry Graduate Teaching Assistants, Amanda Hyett
Electronic Theses and Dissertations
Graduate teaching assistants (GTAs) largely contribute to undergraduate education but are often underprepared for their role as educators. Most graduate students attend graduate school to perform research and are then asked to teach for the first time without sufficient pedagogy training. To assist in increasing the GTAs pedagogical knowledge, a scenario-based activity series was developed and implemented for first- and second-year GTAs. Developing scenario-based scenarios from actual laboratory events provided GTAs with the opportunity to practice prior to engaging in the laboratory classroom. The Teaching Assistant Intervention Activities (TAIAs) included topics such as interpersonal skills and behaviors, group process, working …
Development Of Analytical Methods For Toxic Inhaled Hazards (Tih) And Their Metabolites, Obed Adu Gyamfi
Development Of Analytical Methods For Toxic Inhaled Hazards (Tih) And Their Metabolites, Obed Adu Gyamfi
Electronic Theses and Dissertations
Toxic inhalation hazards (TIHs), such as methyl isocyanate (MIC) and hydrogen cyanide (HCN), are noxious gases and vapors that are harmful, and often deadly, to humans. However, because of their low cost and high reactivity, they are extensively used for industrial productions, creating risk of exposure for both industrial workers (e.g., occupational exposure) and civilians (e.g., accidental release during transport). The illicit use of TIHs, including as terrorist agents, is also concerning. Considering the rapid toxicity of TIHs and the danger they pose to both human and animal lives, there is a critical need to develop of analytical methods for …
Characterization Of Naturally Derived Polymer By Oxidative, Thermal, And Spectrometric Methods, Ranen Roy
Characterization Of Naturally Derived Polymer By Oxidative, Thermal, And Spectrometric Methods, Ranen Roy
Electronic Theses and Dissertations
Extensive use of fossil fuel for different purposes has resulted in significant depletion of it at an alarming rate. Therefore, a potential and sustainable alternative source are badly needed at this moment. Nowadays, lignocellulose biomass is appealing to much interest by the researchers because of its potential nature as a renewable carbon source. It is the most abundant renewable source which is composed of cellulose, hemicellulose, and lignin. Among them, lignin is considered the 2nd most abundantly natural polymer after cellulose which comprises 10-30 % of biomass depending on the source and the environment. Lignin is a three-dimensional cross-linked organic …
Scavenger Hunt: The Search For Sulfur Mustard-Neutralizing Compound In 2-Chloroethyl Ethyl Sulfide (Cees) Treated Human Keratinocyte (Hacat) Epithelial Cells, Tanner Diemer
Electronic Theses and Dissertations
Sulfur mustard is a highly toxic and dangerous vesicant that has been utilized as a chemical warfare agent (CWA) since World War I. Despite its extensive history, an effective antidote to sulfur mustard exposure still does not exist. With detectable levels of unreacted sulfur mustard lasting days after initial contact, a window of opportunity exists to administer a “scavenger” to affected individual immediately and in the days following exposure in hopes of reducing harm by neutralizing unreacted sulfur mustard. For this strategy to be effectively implemented, it is essential to identify a candidate compound with excellent affinity towards sulfur mustard …
Antidiabetic Activity Of Cissus Rotundifolia Plant Growing In Saudi Arabia, Saad Ali Alshehri
Antidiabetic Activity Of Cissus Rotundifolia Plant Growing In Saudi Arabia, Saad Ali Alshehri
Electronic Theses and Dissertations
Diabetes mellitus (DM) is a metabolic disease characterized by high levels of blood glucose resulting from defects in insulin production or action. A world-wide increase in the diabetes rate is projected to reach pandemic levels over the next 10-20 years. Current data shows that high numbers of the population in Saudi Arabia suffer from diabetes and prediabetes. Non-traditional treatments of diabetes from medicinal plants has shown potential antidiabetic activity. A considerable percentage of the population still prefer or use medicinal plants as a treatment or supplement to traditional medicine. Cissus rotundifolia (family Vitaceae) is a known plant in southwestern Saudi …