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Synthesis, Characterization And Stress-Testing Of A Robust Quillaja Saponin Stabilized Oil-In-Water Phytocannabinoid Nanoemulsion, Abhinandan Banerjee, Justin Binder, Rayan Salama, John F. Trant
Synthesis, Characterization And Stress-Testing Of A Robust Quillaja Saponin Stabilized Oil-In-Water Phytocannabinoid Nanoemulsion, Abhinandan Banerjee, Justin Binder, Rayan Salama, John F. Trant
Chemistry and Biochemistry Publications
Background
This study describes the design, optimization, and stress-testing of a novel phytocannabinoid nanoemulsion generated using high-pressure homogenization.QNaturale®" role="presentation">QNaturale®, a plant-derived commercial emulsifier containing quillaja saponin, was used to stabilize the lipid phase droplets in water. Stress-testing was performed on this nanoemulsion in order to evaluate its chemical and colloidal stability under the influence of different environmental factors, encompassing both physical and chemical stressors.
Methods
Extensive optimization studies were conducted to arrive at an ideal nanoemulsion formulation. A coarse emulsion containing 16.6 wt% CBD-enriched cannabis distillate and 83.4 wt% carrier (soybean) oil dispersed in 10 wt%QNaturale®" role="presentation">QNaturale®
(1.5 …