Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 5 of 5
Full-Text Articles in Chemistry
Nicholas Reactions Of Alkynyl- And Alkenyltrifluoroborates, Brent St. Onge, James R. Green
Nicholas Reactions Of Alkynyl- And Alkenyltrifluoroborates, Brent St. Onge, James R. Green
Chemistry and Biochemistry Publications
The Lewis acid mediated Nicholas reaction of potassium alkynyltrifluoroborates and propargyl acetate- hexacarbonyldicobalt complexes affords 1,4-diyne dicobalt hexacarbonyl complexes in good yields. The analogous Nicholas reactions of potassium alkenyltrifluoroborates give 1,3-enyne dicobalt hexacarbonyl complexes in most cases, although the initial site of reaction can vary. Potassium vinyltrifluoroborate itself affords alkynylcyclopropane complexes.
Synthesis Of Tenuifolin Via Intramolecular Nicholas Reaction, Sinisa Djurdjevic, James R. Green
Synthesis Of Tenuifolin Via Intramolecular Nicholas Reaction, Sinisa Djurdjevic, James R. Green
Chemistry and Biochemistry Publications
The synthesis of the Cinnamomum homosesquiterpenoid tenuifolin has been accomplished by way of an intramolecular Nicholas reaction of the [Co2(CO)6] complex of an alkyne-substituted biaryl for construction of the seven-membered ring. The cyclization features the reaction of a nonactivated arene ring with the propargyldicobalt cation to give the dibenzocycloheptyne-Co2(CO)6.
Synthesis Of ‘Spacer’-Naproxen [2-(6-Methoxybiphenylen-2-Yl)Propanoic Acid] And -Isonaproxen [2-(7-Methoxybiphenylen-2-Yl)Propanoic Acid], Juan A. González Gómez, James R. Green, Peter C. Vollhardt
Synthesis Of ‘Spacer’-Naproxen [2-(6-Methoxybiphenylen-2-Yl)Propanoic Acid] And -Isonaproxen [2-(7-Methoxybiphenylen-2-Yl)Propanoic Acid], Juan A. González Gómez, James R. Green, Peter C. Vollhardt
Chemistry and Biochemistry Publications
The CpCo(CO)2-catalyzed cocyclization of 1,2-diethynyl- 4-methoxybenzene with alkynes can be applied to the synthesis of ‘spacer’-naproxen [2-(6-methoxybiphenylen-2-yl)propanoic acid] and its 7-methoxy isomer, ‘spacer’-isonaproxen. While unsymmetrical alkynes are incorporated without regioselectivity, the methoxy group in 6-methoxy-2,3-bis(trimethylsilyl)biphenylene directs electrophiles to C-3, thus allowing for regiochemical differentiation between the 2- and 3-positions.
Benzocycloheptynedicobalt Complexes By Intramolecular Nicholas Reactions, Y. Ding, James R. Green
Benzocycloheptynedicobalt Complexes By Intramolecular Nicholas Reactions, Y. Ding, James R. Green
Chemistry and Biochemistry Publications
Lewis acid mediated intramolecular Nicholas reactions of aryl (Z)-enyne propargyl acetate-CO2(CO)(6) complexes 1 afford benzocycloheptenyne-CO2(CO)(6) complexes 2 and their heterocyclic analogues.
Intramolecular Pauson-Khand Reactions Of Cycloheptynedicobalt Complexes, Ahmed B. Mohamed, James R. Green, Jason Masuda
Intramolecular Pauson-Khand Reactions Of Cycloheptynedicobalt Complexes, Ahmed B. Mohamed, James R. Green, Jason Masuda
Chemistry and Biochemistry Publications
Cycloheptyne-Co-2(CO)(6) complexes bearing alkenes tethered by oxygen, sulfur, and nitrogen atoms undergo Pauson-Khand reactions to afford tricyclic compounds containing a fused 7,5-ring system.