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Full-Text Articles in Chemistry
Azaadamantane Benzamide 5-Ht4 Agonists: Gastrointestinal Prokinetic Sc-54750, Daniel Becker, Daniel L. Flynn, Robert L. Shone, Gary Gullikson
Azaadamantane Benzamide 5-Ht4 Agonists: Gastrointestinal Prokinetic Sc-54750, Daniel Becker, Daniel L. Flynn, Robert L. Shone, Gary Gullikson
Chemistry: Faculty Publications and Other Works
Azaadamantanone 1 was converted to a series of aminoazaadamantane benzamides 9a–d, which were profiled for serotonin receptor activity. Aminomethylazaadamantane SC-54750 is a potent 5-HT4 agonist and 5-HT3 antagonist with in vivo efficacy in gastroparesis models and also inhibits cisplatin-induced emesis.