Chemistry Commons^™

Blood Coagulation Factor Ix: Purification, Activation, Crystallization, Juliet Mcgill

WWU Honors College Senior Projects

This paper presents readers with an optimized procedure for the purification, activation, and crystallization of selected blood coagulation Factor IX double mutant (FIX_2). Through the completion of this work, we aim to enhance future biochemical and structural studies by providing an easier means for the FIX_2 production, in order to increase understanding of the protein’s function within the blood coagulation cascade. The initiation of the blood coagulation cascade is brought on by activation of inactive Factor VIII (FVIII) protein though contact with tissue factor, the FVIII protein then binds to an activated platelet surface where it must wait for its …

Supporting Data For Impact Of The Macrophyte Nymphaea Odorata (Lily Pads) On Dissolved Organic Matter (Dom) In A Lake, Kyle Juetten, Warren J. De Bruyn, Zachary Landram, Aaron Harrison, Angela Strecker, Catherine D. Clark

Chemistry Faculty and Staff Publications

(Files are available for download below.)

This is supporting data for a publication on the role of lily pads in contributing to the dissolved organic matter pool in Lake Louise, a small lake in the Pacific Northwest region of the USA. Specifically, this data includes the absorbance and fluorescence spectra of the Lake Louise water samples (taken weekly over the course of 2018). These files include large spreadsheets with raw and corrected absorbance and fluorescence intensity data as a function of wavelength, as well as the raw and corrected absorbance and fluorescence 3D excitation-emission matrix spectra (EEMs). These files are …

Investigations On The Active Catalyst In Pd Catalyzed Organic Reactions, Riley Mcgraw

WWU Honors College Senior Projects

Cross coupling and C-H functionalization reactions are valuable tools in the synthesis of pharmaceuticals, natural products, fine chemicals, and electronics. Molecular precatalysts are frequently used in both reactions but because the reactions use conditions like those employed in intentional preparation of nanoparticles, the presence of nanoparticles is highly likely for both systems. In the case of the cross-coupling reaction, nanoparticles have been shown to have catalytic relevance, but C-H functionalization reactions are widely thought to occur by means of a homogenous catalyst. To better understand the state of the active catalyst, a method of homogeneity analysis by centrifuge is proposed. …

Synthesis And Characterization Of Hydroxy-Functionalized Copper Indium Disulfide Quantum Dots, Julia Schexnayder

WWU Honors College Senior Projects

Quantum dots offer tunable electronic and optical properties due to the quantum confinement effect, making them desirable for various applications. However, their native hydrophobic form requires surface chemistry modification for certain applications. This research explores the method of ligand exchange using 11-mercapto-1-undecanol for improving the stability of copper indium disulfide (CIS) quantum dot (QD) nanoparticles in polar environments. The effects of this ligand exchange on QD chemical composition, optical properties, hydroxy-reactivity, and hydrodynamic radius are characterized. Analysis of characterization results indicates successful surface modification through hydroxyfunctionalization, as confirmed by 1H-NMR and IR spectroscopy. The desired optical properties of the QDs …