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Full-Text Articles in Chemistry
Characterization And Reaction Of An Analog Of The Anticancer Drug Oxaliplatin, Jonathan D. Hendrie
Characterization And Reaction Of An Analog Of The Anticancer Drug Oxaliplatin, Jonathan D. Hendrie
Mahurin Honors College Capstone Experience/Thesis Projects
Oxaliplatin is an anticancer drug that reacts with DNA, RNA, and proteins both in vitro and in vivo. Our research focuses on synthesizing analogs of oxaliplatin and understanding how bulky ligand groups affect reaction with amino acids. (R,R)-N,N’-dimethyl-1,2-diaminocyclohexane platinum(II) oxalate or Pt(Me2dach)(ox) varies from oxaliplatin or Pt(dach)(ox) in that it has one methyl group attached to each platinum coordinated nitrogen. Nuclear Magnetic Resonance (NMR) spectroscopy has shown that the reactions of N-Acetylmethionine (N-AcMet) with Pt(Me2dach)(ox) and Pt(dach)(ox) proceed at similar rates suggesting that the methyl groups of Pt(Me2dach)(ox) have little effect on the initial reaction. Whereas the reaction of Pt(dach)(ox) …
Reactions Of Platinum(Ii) Compounds With Selenium Containing Amino Acids, Stephanie Robey
Reactions Of Platinum(Ii) Compounds With Selenium Containing Amino Acids, Stephanie Robey
Masters Theses & Specialist Projects
Platinum(II) anticancer medications essentially react with DNA forming kinks in
the double helix of DNA and causing apoptosis. It has also been noted that these
anticancer medications react with methionine and cysteine in the body. With the new discoveries of selenium containing amino acids including selenomethionine and selenocysteine, new research is ongoing to see what types of products can be formed from these amino acids. Our research reacts [Pt(Met-S,N)Cl2] 2+ with selenomethionine to determine what types of products are produced. Monochelates including [Pt(SeMet-Se,N)Cl2] 2+ have formed two isomers, …